Two mechanisms of oral malodor inhibition by zinc ions.
Two mechanisms of oral malodor inhibition by zinc ions.
复制标题
锌离子口服疾病抑制的两种机制。
DOI：
10.1590/1678-7757-2017-0161
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发表时间：
2018-01-18
期刊：
影响因子：
--
通讯作者：
Hanioka T
中科院分区：
文献类型：
--
作者：
Suzuki N;Nakano Y;Watanabe T;Yoneda M;Hirofuji T;Hanioka T
本研究的目的是揭示锌离子抑制口腔异味的机制。与其他金属离子相比，锌离子与气态硫化氢（H2S）的直接结合进行了评估。检测了9种金属氯化物和6种金属醋酸盐。为了了解抑制H2S挥发的强度，采用串联稀释法确定了抑制H2S挥发所需的最小浓度。随后，研究了锌离子对6株与挥发性硫化合物（VSC）生产有关的口腔细菌和3株与VSC生产无关的口腔细菌的生长抑制活性。ZnCl2、CdCl2、CuCl2、（CH3COO）2Zn、（CH3COO）2Cd、（CH3COO）2Cu和CH3COOAg的水溶液几乎完全抑制H2S的挥发。抑制H2S挥发的强度依次为Ag+ > Cd2+ > Cu2+ > Zn2+。锌离子对口腔细菌生长的影响呈菌株依赖性。其中，核梭杆菌ATCC 25586在含锌量为0.001%的培养基中受抑率最高。锌离子对口腔异味的抑制机制主要包括与气态H2S直接结合和抑制产生vsc的口腔细菌生长两种机制。
The aim of this study was to reveal the mechanisms by which zinc ions inhibit oral malodor. The direct binding of zinc ions to gaseous hydrogen sulfide (H2S) was assessed in comparison with other metal ions. Nine metal chlorides and six metal acetates were examined. To understand the strength of H2S volatilization inhibition, the minimum concentration needed to inhibit H2S volatilization was determined using serial dilution methods. Subsequently, the inhibitory activities of zinc ions on the growth of six oral bacterial strains related to volatile sulfur compound (VSC) production and three strains not related to VSC production were evaluated. Aqueous solutions of ZnCl2, CdCl2, CuCl2, (CH3COO)2Zn, (CH3COO)2Cd, (CH3COO)2Cu, and CH3COOAg inhibited H2S volatilization almost entirely. The strengths of H2S volatilization inhibition were in the order Ag+ > Cd2+ > Cu2+ > Zn2+. The effect of zinc ions on the growth of oral bacteria was strain-dependent. Fusobacterium nucleatum ATCC 25586 was the most sensitive, as it was suppressed by medium containing 0.001% zinc ions. Zinc ions have an inhibitory effect on oral malodor involving the two mechanisms of direct binding with gaseous H2S and suppressing the growth of VSC-producing oral bacteria.
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影响因子：
--
作者：
PERSSON, S;EDLUND, MB;CARLSSON, J
通讯作者：
CARLSSON, J
影响因子：
6.7
作者：
Witt, Jon;Bsoul, Samer;Hamilton, Amy
通讯作者：
Hamilton, Amy
影响因子：
3
作者：
TONZETICH, J
通讯作者：
TONZETICH, J
影响因子：
6.7
作者：
Berchier, C. E.;Slot, D. E.;Van der Weijden, G. A.
通讯作者：
Van der Weijden, G. A.
影响因子：
3.3
作者：
Lynch, E;Sheerin, A;Grootveld, M
通讯作者：
Grootveld, M