Possible interruption of malaria transmission, highland Kenya, 2007-2008.

Possible interruption of malaria transmission, highland Kenya, 2007-2008.
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DOI:
10.3201/eid1512.090627
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发表时间:
2009-12
影响因子:
11.8
通讯作者:
Akhwale W
Akhwale W
中科院分区:
医学2区
文献类型:
--
作者:
John CC;Riedesel MA;Magak NG;Lindblade KA;Menge DM;Hodges JS;Vulule JM;Akhwale W

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每年喷洒杀虫剂和青蒿素联合治疗可阻止传播。疟疾传播不稳定的高原地区是消除疟疾的目标,因为在旱季传播减少到低水平。在肯尼亚Kipsamoite和Kapsisiywa的高地地区(人口约7400人),从2005年开始每年使用合成拟除虫菊酯类杀虫剂进行家庭室内残留喷洒,并于2006年10月开始将蒿甲醚/甲基苯胺作为一线疟疾治疗方法。2007年4月至2008年3月期间,在这些地点没有发生显微镜确诊的疟疾病例。在2007年5月至2008年4月期间对无症状者进行的4次评估中,在任何时间通过显微镜或PCR检测出无性恶性疟原虫阳性的人总数小于0.3%,在最后2次样本采集中没有人通过PCR检测出阳性。我们的研究结果表明,在这些地区,通过广泛的家庭室内残留喷洒和青蒿素联合治疗,可以中断并最终消除疟疾传播。
Annual insecticide spraying and artemisinin combination therapy may stop transmission. Highland areas where malaria transmission is unstable are targets for malaria elimination because transmission decreases to low levels during the dry season. In highland areas of Kipsamoite and Kapsisiywa, Kenya (population ≈7,400 persons), annual household indoor residual spraying with a synthetic pyrethroid was performed starting in 2005, and artemether/lumefantrine was implemented as first-line malaria treatment in October 2006. During April 2007–March 2008, no microscopy-confirmed cases of malaria occurred at the sites. In 4 assessments of asymptomatic persons during May 2007–April 2008, a total of <0.3% of persons were positive for asexual Plasmodium falciparum by microscopy or PCR at any time, and none were positive by PCR at the last 2 sample collections. Our findings show that in such areas, interruption and eventual elimination of malaria transmission may be achievable with widespread annual indoor residual spraying of households and artemisinin combination therapy.
DOI: 10.1016/j.actatropica.2008.05.001
发表时间: 2008-08-01
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发表时间: 2005-04-01
期刊: PLOS MEDICINE
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