Role of chemokines in the enhancement of BBB permeability and inflammatory infiltration after rabies virus infection.
Role of chemokines in the enhancement of BBB permeability and inflammatory infiltration after rabies virus infection.
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DOI：
10.1016/j.virusres.2009.03.014
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发表时间：
2009-09
期刊：
影响因子：
5
通讯作者：
Fu, Zhen F.
中科院分区：
文献类型：
--
作者：
Kuang, Yi;Lackay, Sarah N.;Zhao, Ling;Fu, Zhen F.
据报道，狂犬病病毒（RABV）感染诱导先天免疫，特别是通过诱导干扰素和趋化因子，与致病性呈负相关。为了进一步研究趋化因子的表达与RABV感染之间的关系，我们给Balb/c小鼠肌肉注射实验室减毒RABV （B2C）和野生型RABV （wt）。在感染后的不同时间点评估趋化因子表达、炎症细胞浸润和血脑屏障（BBB）通透性。感染后第3天，与模拟感染小鼠相比，感染两种病毒的小鼠中枢神经系统（CNS）几乎没有炎症，血脑屏障的通透性没有改变。在第6天，B2C感染诱导炎症趋化因子的表达和炎症细胞浸润到中枢神经系统，而这些变化在drv感染小鼠中最小。此外，与DRV感染相比，B2C感染显著提高了血脑屏障的通透性。在上调的趋化因子中，IP-10的表达与炎症细胞浸润中枢神经系统和血脑屏障通透性增强的相关性最强。这些数据表明，实验室减毒的RABV诱导趋化因子的表达和炎症细胞浸润到中枢神经系统。B2C对趋化因子的上调可能触发血脑屏障通透性的改变，这有助于炎症细胞浸润到中枢神经系统，从而减弱RABV。
Induction of innate immunity, particularly through the induction of interferon and chemokines, by rabies virus (RABV) infection has been reported to be inversely correlated with pathogenicity. To further investigate the association between the expression of chemokines and RABV infection, laboratory-attenuated RABV (B2C) and wild-type (wt) RABV (DRV) were administered to Balb/c mice intramuscularly. Chemokine expression, inflammatory cell infiltration, and blood-brain barrier (BBB) permeability were evaluated at various time points after infection. At day 3 post infection (p.i.) there was very little inflammation in the central nervous system (CNS) and BBB permeability did not change in mice infected with either virus when compared with mock-infected mice. At 6 day p.i., infection with B2C induced the expression of inflammatory chemokines and infiltration of inflammatory cells into the CNS, while these changes were minimal in DRV-infected mice. Furthermore, infection with B2C significantly enhanced BBB permeability comparing to infection with DRV. Among the upregulated chemokines, the expression of IP-10 was best correlated with infiltration of inflammatory cells into the CNS and enhancement of BBB permeability. These data indicate that laboratory-attenuated RABV induces expression of chemokines and infiltration of inflammatory cells into the CNS. Upregulation of chemokines by B2C may have triggered the change in BBB permeability, which helps infiltration of inflammatory cells into the CNS, and thus attenuation of RABV.
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影响因子：
5.5
作者：
Fu, ZF
通讯作者：
Fu, ZF
影响因子：
4.4
作者：
Phares, Timothy W.;Fabis, Marzena J.;Hooper, D. Craig
通讯作者：
Hooper, D. Craig
影响因子：
4.2
作者：
Man, Shu-Mei;Ma, Yi-Ran;Chen, Yu-Hua
通讯作者：
Chen, Yu-Hua
DOI：
10.1084/jem.125.3.447
发表时间：
1967-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Miyamoto K;Matsumoto S
通讯作者：
Matsumoto S
DOI：
10.1073/pnas.80.1.70
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DIETZSCHOLD, B;WUNNER, WH;KOPROWSKI, H
通讯作者：
KOPROWSKI, H