Inhibitory Effects of TRK-530 on Rat Adjuvant Arthritis
Inhibitory Effects of TRK-530 on Rat Adjuvant Arthritis
复制标题
TRK-530 对大鼠佐剂关节炎的抑制作用
作者：
Masahiko Tanahashi;Y. Funaba;M. Itoh;N. Kawabe;Teruo Nakadate
TRK-530是一种新型的双膦酸盐衍生物。我们检查了TRK-530对佐剂性关节炎（AA）大鼠的抗炎作用。当TRK-530以2.5mg/kg的剂量给药AA大鼠2周时，它抑制了关节炎关节的破坏性变化，如爪水肿、骨丢失和关节变性。TRK-530还抑制脾肿大并抑制血清唾液酸的增加，血清唾液酸作为炎症的全身参数测量。为了阐明TRK-530的抑制机制，将给予TRK-530的AA大鼠与对照大鼠中驻留的腹腔巨噬细胞的白细胞介素-1（IL-1）样活性进行比较。我们发现TRK-530在给药后6周抑制细菌脂多糖诱导的IL-1样活性，而对照大鼠的IL-1样活性仍处于高水平。这些发现表明TRK-530对AA大鼠具有抗炎活性。
TRK-530 is a novel bisphosphonate derivative. We examined the anti-inflammatory effects of TRK-530 on adjuvant arthritis (AA) rats. When TRK-530 at a dose of 2.5 mg/kg was administered for 2 weeks to AA rats, it inhibited destructive changes in arthritic joints such as paw edema, bone loss and joint degeneration. TRK-530 also inhibited splenomegaly and suppressed the increase in serum sialic acid which is measured as a systemic parameter of inflammation. To clarify the inhibitory mechanism of TRK-530, interleukin-1 (IL-1)-like activities of resident peritoneal macrophages in AA rats given TRK-530 were compared with those of control rats. We found that TRK-530 inhibited IL-1-like activity induced by bacterial lipopolysaccharide 6 weeks after administration when the IL-1-like activities of control rats were still at high levels. These findings suggest that TRK-530 exerts anti-inflammatory activities in AA rats.
影响因子：
4.2
作者：
D. Magilavy
通讯作者：
D. Magilavy
DOI：
10.1056/nejm199301143280207
发表时间：
1993-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
C. Dinarello;S. Wolff
通讯作者：
C. Dinarello;S. Wolff