Curating a knowledge base for individuals with coinfection of HIV and SARS-CoV-2: a study protocol of EHR-based data mining and clinical implementation.
Curating a knowledge base for individuals with coinfection of HIV and SARS-CoV-2: a study protocol of EHR-based data mining and clinical implementation.
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DOI：
10.1136/bmjopen-2022-067204
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发表时间：
2022-09-13
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
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作者：
尽管艾滋病毒感染者患严重COVID-19疾病的风险较高，但SARS-CoV-2和艾滋病毒感染之间的相互作用仍不清楚。为了描述这些相互作用，多中心电子健康记录（EHR）保持现有的承诺，提供全方位和纵向的临床数据，人口统计学和社会行为数据在个人层面。目前，一个全面的EHR为基础的队列艾滋病毒/SARS-CoV-2合并感染尚未建立; EHR整合和数据挖掘方法，为研究合并感染是迫切需要的，但仍然欠发达。这项探索性/发展性研究的总体目标是为HIV/SARS-CoV-2合并感染的个体建立一个基于EHR的队列，并进行大规模基于EHR的数据挖掘，以检查HIV和SARS-CoV-2感染之间的相互作用，并系统地识别和验证导致合并感染严重临床病程的因素。我们将使用美国全国性的EHR数据库，即国家COVID队列协作（N3 C）。最终，收集到的临床证据将被实施并用于对临床决策支持原型进行试点测试，以帮助提供者在现实世界的诊所中筛查和转诊高危患者。本研究已获得南卡罗来纳州机构审查委员会批准（Pro 00121828），作为非人类受试者研究。研究结果将在学术会议上发表，并发表在同行评审的期刊上。这项研究将传播急需的临床证据，以指导Prisma Health（一个合作的医疗保健系统）合并感染个体的临床实践。
Despite a higher risk of severe COVID-19 disease in individuals with HIV, the interactions between SARS-CoV-2 and HIV infections remain unclear. To delineate these interactions, multicentre Electronic Health Records (EHR) hold existing promise to provide full-spectrum and longitudinal clinical data, demographics and sociobehavioural data at individual level. Presently, a comprehensive EHR-based cohort for the HIV/SARS-CoV-2 coinfection has not been established; EHR integration and data mining methods tailored for studying the coinfection are urgently needed yet remain underdeveloped. The overarching goal of this exploratory/developmental study is to establish an EHR-based cohort for individuals with HIV/SARS-CoV-2 coinfection and perform large-scale EHR-based data mining to examine the interactions between HIV and SARS-CoV-2 infections and systematically identify and validate factors contributing to the severe clinical course of the coinfection. We will use a nationwide EHR database in the USA, namely, National COVID Cohort Collaborative (N3C). Ultimately, collected clinical evidence will be implemented and used to pilot test a clinical decision support prototype to assist providers in screening and referral of at-risk patients in real-world clinics. The study was approved by the institutional review boards at the University of South Carolina (Pro00121828) as non-human subject study. Study findings will be presented at academic conferences and published in peer-reviewed journals. This study will disseminate urgently needed clinical evidence for guiding clinical practice for individuals with the coinfection at Prisma Health, a healthcare system in collaboration.
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DOI：
10.1093/infdis/jiab114
发表时间：
2021-11-16
期刊：
The Journal of infectious diseases
影响因子：
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作者：
Eisinger RW;Lerner AM;Fauci AS
通讯作者：
Fauci AS
影响因子：
11.8
作者：
Dandachi, Dima;Geiger, Grant;Chow, Jeremy
通讯作者：
Chow, Jeremy
影响因子：
11.1
作者：
Deer RR;Rock MA;Vasilevsky N;Carmody L;Rando H;Anzalone AJ;Basson MD;Bennett TD;Bergquist T;Boudreau EA;Bramante CT;Byrd JB;Callahan TJ;Chan LE;Chu H;Chute CG;Coleman BD;Davis HE;Gagnier J;Greene CS;Hillegass WB;Kavuluru R;Kimble WD;Koraishy FM;Köhler S;Liang C;Liu F;Liu H;Madhira V;Madlock-Brown CR;Matentzoglu N;Mazzotti DR;McMurry JA;McNair DS;Moffitt RA;Monteith TS;Parker AM;Perry MA;Pfaff E;Reese JT;Saltz J;Schuff RA;Solomonides AE;Solway J;Spratt H;Stein GS;Sule AA;Topaloglu U;Vavougios GD;Wang L;Haendel MA;Robinson PN
通讯作者：
Robinson PN
影响因子：
4.6
作者：
Castillo-Mancilla JR;Haberer JE
通讯作者：
Haberer JE
DOI：
10.15585/mmwr.mm6945e2
发表时间：
2020-11-13
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Lavery AM;Preston LE;Ko JY;Chevinsky JR;DeSisto CL;Pennington AF;Kompaniyets L;Datta SD;Click ES;Golden T;Goodman AB;Mac Kenzie WR;Boehmer TK;Gundlapalli AV
通讯作者：
Gundlapalli AV