Differential coupling between subcortical calcium and BOLD signals during evoked and resting state through simultaneous calcium fiber photometry and fMRI
Differential coupling between subcortical calcium and BOLD signals during evoked and resting state through simultaneous calcium fiber photometry and fMRI
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通过同步钙纤维光度测定和功能磁共振成像，在诱发和静息状态下皮层下钙和 BOLD 信号之间的差分耦合
DOI：
10.1016/j.neuroimage.2019.07.006
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发表时间：
2019-10
期刊：
影响因子：
5.7
通讯作者：
Liang Zhifeng
中科院分区：
文献类型：
--
作者：
Tong Chuanjun;Dai Jian-kun;Chen Yuyan;Zhang Kaiwei;Feng Yanqiu;Liang Zhifeng
基于任务和静息状态的功能磁共振成像已被广泛应用于脑功能研究。作为功能磁共振成像的基础，BOLD信号的潜在神经基础已被广泛研究，但其详细机制尚不清楚，特别是在静息状态下。为了检查神经血管耦合，同时记录神经和血管信号是很重要的。在这里，我们开发了一种基于相机的新型装置，可扩展的同时钙纤维光度测定和大鼠的功能磁共振成像。利用该装置，我们在视觉刺激和静息状态下同时记录了上丘（SC）、外侧膝状核（LGN）和功能磁共振成像（fMRI）的钙信号。我们的研究结果显示，在任务状态下，钙和BOLD信号之间存在强大的区域特异性耦合，而在静息状态下，钙和BOLD信号之间存在较弱的全脑相关性。有趣的是，在对fMRI数据中的白质、脑室信号和全局信号进行回归后，这种相关性在静息状态下的空间特异性得到了提高。综上所述，我们的研究结果表明，在激活状态和静息状态下，皮层下区域钙和BOLD信号的耦合存在差异，而静息状态下的耦合关系与静息状态下BOLD预处理策略有关。
Task based and resting state fMRI has been widely utilized to study brain functions. As the foundation of fMRI, the underlying neural basis of the BOLD signal has been extensively studied, but the detailed mechanism remains elusive, particularly during the resting state. To examine the neurovascular coupling, it is important to simultaneously record neural and vascular signals. Here we developed a novel setup of camera based, scalable simultaneous calcium fiber photometry and fMRI in rats. Using this setup, we recorded calcium signals of superior colliculus (SC) and lateral geniculate nucleus (LGN) and fMRI simultaneously during visual stimulation and the resting state. Our results revealed robust, region-specific coupling between calcium and BOLD signals in the task state and weaker, whole brain correlation in the resting state. Interestingly, the spatial specificity of such correlation in the resting state was improved upon regression of white matter, ventricle signals and global signals in fMRI data. Overall, our results suggest differential coupling of calcium and BOLD signals for subcortical regions between evoked and resting states, and the coupling relationship in the resting state was related with resting state BOLD preprocessing strategies.
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影响因子：
48
作者：
Kim CK;Yang SJ;Pichamoorthy N;Young NP;Kauvar I;Jennings JH;Lerner TN;Berndt A;Lee SY;Ramakrishnan C;Davidson TJ;Inoue M;Bito H;Deisseroth K
通讯作者：
Deisseroth K
DOI：
10.1177/1073858418805427
发表时间：
2019-08
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Drew PJ;Winder AT;Zhang Q
通讯作者：
Zhang Q
DOI：
10.1177/0271678x15619428
发表时间：
2016-11
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Schmid F;Wachsmuth L;Schwalm M;Prouvot PH;Jubal ER;Fois C;Pramanik G;Zimmer C;Faber C;Stroh A
通讯作者：
Stroh A
影响因子：
9.2
作者：
Goense, Jozien B. M.;Logothetis, Nikos K.
通讯作者：
Logothetis, Nikos K.
影响因子：
48
作者：
Schulz, Kristina;Sydekum, Esther;Helmchen, Fritjof
通讯作者：
Helmchen, Fritjof