Comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathy.
Comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathy.
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DOI：
10.1186/s12938-020-00838-4
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发表时间：
2021-01-12
影响因子：
3.9
通讯作者：
Tang D
中科院分区：
文献类型：
--
作者：
Huang X;Deng L;Zuo H;Yang C;Song Y;Lesperance M;Tang D
患者特异性主动流体结构相互作用（FSI）模型是一种有效的无创研究心脏血流动力学的方法。然而，主动计算模型需要耗费大量的精力才能获得合适的外力边界条件，这严重制约了主动计算模型的临床应用。根据6例患者术前、术后CT图像，将12个被动式FSI模型的模拟结果与相应的主动模型进行比较，探讨不同模型在血流动力学和心脏力学方面的差异。对比被动模型和主动模型，发现在sam前时间点二尖瓣小叶（MVL）的压差和剪切应力无显著差异，但左心室（心内膜）内边界壁面应力有显著差异。我们还发现，无论是主动模型还是被动模型，手术成功后，包覆MVL上的压差和MVL上的剪切应力均显著降低。我们的研究结果表明，被动模型可以在5% RR区间内提供良好的近似血流动力学结果，这对于分析收缩前运动（SAM）的起始至关重要。与主动模型相比，被动模型大大降低了建模的复杂性和收敛的难度。这些结果表明，在适当的边界条件和足够的临床数据下，被动计算模型可能是一个很好的替代主动模型来进行SAM启动的血流动力学分析。
Patient-specific active fluid–structure interactions (FSI) model is a useful approach to non-invasively investigate the hemodynamics in the heart. However, it takes a lot of effort to obtain the proper external force boundary conditions for active models, which heavily restrained the time-sensitive clinical applications of active computational models. The simulation results of 12 passive FSI models based on 6 patients’ pre-operative and post-operative CT images were compared with corresponding active models to investigate the differences in hemodynamics and cardiac mechanics between these models. In comparing the passive and active models, it was found that there was no significant difference in pressure difference and shear stress on mitral valve leaflet (MVL) at the pre-SAM time point, but a significant difference was found in wall stress on the inner boundary of left ventricle (endocardium). It was also found that pressure difference on the coapted MVL and the shear stress on MVL were significantly decreased after successful surgery in both active and passive models. Our results suggested that the passive models may provide good approximated hemodynamic results at 5% RR interval, which is crucial for analyzing the initiation of systolic anterior motion (SAM). Comparing to active models, the passive models decrease the complexity of the modeling construction and the difficulty of convergence significantly. These findings suggest that, with proper boundary conditions and sufficient clinical data, the passive computational model may be a good substitution model for the active model to perform hemodynamic analysis of the initiation of SAM.
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DOI：
10.1115/1.2913339
发表时间：
2008-08
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Tang D;Yang C;Geva T;Del Nido PJ
通讯作者：
Del Nido PJ
影响因子：
4.1
作者：
Baillargeon, Brian;Rebelo, Nuno;Fox, David D.;Taylor, Robert L.;Kuhl, Ellen
通讯作者：
Kuhl, Ellen
基于 CT 的患者特异性肥厚性梗阻性心肌病左心室 3D 被动 FSI 模型
DOI：
10.1080/10255842.2018.1443215
发表时间：
2018-03
影响因子：
1.6
作者：
Deng L;Huang X;Yang C;Song Y;Tang D
通讯作者：
Tang D
DOI：
10.1098/rsta.2009.0091
发表时间：
2009-09-13
影响因子：
5
作者：
Holzapfel, Gerhard A.;Ogden, Ray W.
通讯作者：
Ogden, Ray W.
影响因子：
4.3
作者：
Niederer SA;Smith NP
通讯作者：
Smith NP