Inflammatory Pathways in Psychiatric Disorders: The case of Schizophrenia and Depression.
Inflammatory Pathways in Psychiatric Disorders: The case of Schizophrenia and Depression.
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DOI：
10.1007/s40473-020-00207-4
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发表时间：
2020-09
影响因子：
1.7
通讯作者：
Pillai A
中科院分区：
文献类型：
--
作者：
Feng T;Tripathi A;Pillai A
更好地了解抑郁症和精神分裂症病理生理学背后的关键分子/途径可能有助于制定新的治疗策略。在这篇综述中，我们讨论了炎症通路在抑郁症和精神分裂症发病机制中的作用的最新进展。炎症是一种先天免疫反应，可由多种因素触发，包括病原体、压力和损伤。在正常情况下，病原体清除和组织修复后炎症反应会平静。然而，异常的长期或慢性炎症可能会导致破坏性影响。越来越多的证据表明，炎症失调与神经精神疾病的发病机制有关。在这篇综述中，我们讨论了补体系统、外周免疫细胞浸润中枢神经系统 (CNS)、肠-脑轴以及犬尿氨酸通路在抑郁症和精神分裂症中的作用。有大量令人信服的证据表明炎症通路在抑郁症和精神分裂症中的作用。尽管这些发现中的大多数都显示了它们在上述疾病的病理生理学中的作用，但有必要进行更多的研究来调查本文中讨论的各种免疫信号靶点的治疗潜力。
A better understanding of the key molecules/pathways underlying the pathophysiology of depression and schizophrenia may contribute to novel therapeutic strategies. In this review, we have discussed the recent developments on the role of inflammatory pathways in the pathogenesis of depression and schizophrenia. Inflammation is an innate immune response that can be triggered by various factors, including pathogens, stress and injury. Under normal conditions, the inflammatory responses quiet after pathogen clearance and tissue repair. However, abnormal long-term or chronic inflammation can lead to damaging effects. Accumulating evidence suggest that dysregulated inflammation is linked to the pathogenesis of neuropsychiatric disorders. In this review, we have discussed the roles of complement system, infiltration of peripheral immune cells into the central nervous system (CNS), the gut-brain axis, and the kynurenine pathway in depression and schizophrenia. There is a large body of compelling evidence on the role of inflammatory pathways in depression and schizophrenia. Although most of these findings show their roles in the pathophysiology of the above disorders, additional studies are warranted to investigate the therapeutic potential of various immune signaling targets discussed in this article.
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影响因子：
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作者：
Dantzer R
通讯作者：
Dantzer R
影响因子：
3.3
作者：
Felger JC;Lotrich FE
通讯作者：
Lotrich FE
影响因子：
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作者：
Focking, Melanie;Sabherwal, Sophie;Cotter, David R.
通讯作者：
Cotter, David R.
影响因子：
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作者：
Aguliar-Valles, A.;Kim, J.;Luheshi, G. N.
通讯作者：
Luheshi, G. N.
影响因子：
4.4
作者：
Bennabi, L. D.;Charpeaud, T.;Haffen, E.
通讯作者：
Haffen, E.