Neutrophils in cancer carcinogenesis and metastasis.
Neutrophils in cancer carcinogenesis and metastasis.
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中性粒细胞在癌症发生和转移中的作用
DOI：
10.1186/s13045-021-01187-y
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发表时间：
2021-10-21
影响因子：
28.5
通讯作者：
Cheng L
中科院分区：
文献类型：
--
作者：
Xiong S;Dong L;Cheng L
近年来，中性粒细胞因其促癌作用而受到越来越多的关注。中性粒细胞与淋巴细胞比值升高被认为是癌症患者的预后指标。嗜中性粒细胞不再被视为具有单一功能的先天免疫细胞，更不是癌症病理过程中的旁观者。它们的多样性和可塑性正日益得到承认。本文综述了中性粒细胞在肿瘤发生、发展、转移和复发中的作用和机制。尽管研究结果存在争议，但中性粒细胞在促进和抑制癌症方面发挥双重作用这一事实是不可否认的。中性粒细胞的可塑性使其能够适应不同的癌症微环境，对癌症发挥不同的作用。鉴于我们自己的研究结果，我们提出了一个合理的假设，即中性粒细胞可能在癌症微环境中被重新编程为促进癌症的状态。这一新的观点表明，中性粒细胞重编程在癌症治疗过程中是一个值得关注的问题。预防或逆转中性粒细胞的重编程可能是辅助癌症治疗的潜在策略。
In recent years, neutrophils have attracted increasing attention because of their cancer-promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic indicator for patients with cancer. Neutrophils are no longer regarded as innate immune cells with a single function, let alone bystanders in the pathological process of cancer. Their diversity and plasticity are being increasingly recognized. This review summarizes previous studies assessing the roles and mechanisms of neutrophils in cancer initiation, progression, metastasis and relapse. Although the findings are controversial, the fact that neutrophils play a dual role in promoting and suppressing cancer is undeniable. The plasticity of neutrophils allows them to adapt to different cancer microenvironments and exert different effects on cancer. Given the findings from our own research, we propose a reasonable hypothesis that neutrophils may be reprogrammed into a cancer-promoting state in the cancer microenvironment. This new perspective indicates that neutrophil reprogramming in the course of cancer treatment is a problem worthy of attention. Preventing or reversing the reprogramming of neutrophils may be a potential strategy for adjuvant cancer therapy.
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DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
与肿瘤相关的CD66B+中性粒细胞计数是局部宫颈癌复发的独立预后因素。
影响因子：
8.8
作者：
Carus A;Ladekarl M;Hager H;Nedergaard BS;Donskov F
通讯作者：
Donskov F
影响因子：
29.4
作者：
Bui, Triet M.;Butin-Israeli, Veronika;Sumagin, Ronen
通讯作者：
Sumagin, Ronen
影响因子：
64.5
作者：
Acharyya S;Oskarsson T;Vanharanta S;Malladi S;Kim J;Morris PG;Manova-Todorova K;Leversha M;Hogg N;Seshan VE;Norton L;Brogi E;Massagué J
通讯作者：
Massagué J
影响因子：
50.3
作者：
Ahn, G-One;Brown, J. Martin
通讯作者：
Brown, J. Martin