Tumour-associated CD66b+ neutrophil count is an independent prognostic factor for recurrence in localised cervical cancer.
Tumour-associated CD66b+ neutrophil count is an independent prognostic factor for recurrence in localised cervical cancer.
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与肿瘤相关的CD66B+中性粒细胞计数是局部宫颈癌复发的独立预后因素。
DOI：
10.1038/bjc.2013.167
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发表时间：
2013-05-28
影响因子：
8.8
通讯作者：
Donskov F
中科院分区：
文献类型：
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作者：
Carus A;Ladekarl M;Hager H;Nedergaard BS;Donskov F
促肿瘤免疫细胞对宫颈癌的预后影响尚不清楚。妇产科联合会(FIGO)IB期和IIA期宫颈癌患者(N=101例)采用免疫组织化学方法检测肿瘤相关CD66b+中性粒细胞和CD163+巨噬细胞。研究结果与同一队列中肿瘤浸润性CD3+、CD4+和CD8+淋巴细胞的先前结果相关，以无复发生存期(RFS)为终点。CD66b+中性粒细胞和CD163+巨噬细胞密度以瘤周室最高(中位数分别为53.1 细胞 mm−2和1.3%面积分数)。瘤周和间质CD66b+中性粒细胞及瘤周CD163+巨噬细胞与短射频显著相关。多因素分析显示，瘤周高中性粒细胞(HR2.27；95%CI1.09~4.75；P=0.03)、低CD8+淋巴细胞(HR3.67；95%CI1.63~8.25；P=0.002)和淋巴结转移(HR2.70；95%CI1.26~5.76；P=0.01)是影响短期RFS的独立预后因素，而CD163+巨噬细胞无显著意义。瘤内和瘤周CD66b+中性粒细胞对CD8+淋巴细胞的联合指标对各四分位数有较好的区分率，5年RFS分别为92%、80%、62%和44%(P=0.001)。肿瘤相关的中性粒细胞计数是局部宫颈癌患者短期RFS的独立预后因素。CD66b和CD8联合应用可进一步改善预后分层。这些发现需要前瞻性的验证。
The prognostic impact of tumour-promoting immune cells in cervical cancer is unclear. Federation of Gynaecology and Obstetrics (FIGO) stage IB and IIA cervical cancer patients (N=101) were assessed for tumour-associated CD66b+ neutrophils and CD163+ macrophages by immunohistochemistry in whole tissue sections using stereology. Results were correlated with previous results on tumour-infiltrating CD3+, CD4+, and CD8+ lymphocytes in the same cohort with recurrence-free survival (RFS) as end point. The highest densities of CD66b+ neutrophils and CD163+ macrophages were observed in the peritumoural compartment (median 53.1 cells mm−2 and 1.3% area fraction, respectively). Above median peritumoural and stromal CD66b+ neutrophils and peritumoural CD163+ macrophages were significantly associated with short RFS. Multivariate analysis identified high peritumoural neutrophils (HR 2.27; 95% CI 1.09–4.75; P=0.03), low peritumoural CD8+ lymphocytes (HR 3.67; 95% CI 1.63–8.25; P=0.002), and lymph node metastases (HR 2.70; 95% CI 1.26–5.76; P=0.01) as independent prognostic factors for short RFS, whereas CD163+ macrophages were not significant. An index of combined intratumoral and peritumoral CD66b+ neutrophils to CD8+ lymphocytes had good discriminatory power for each quartile with 5-year RFS of 92%, 80%, 62%, and 44% (P=0.001). Tumour-associated neutrophil count is an independent prognostic factor for short RFS in localised cervical cancer. Combining CD66b and CD8 may further improve prognostic stratification. These findings require prospective validation.
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影响因子：
8.8
作者：
Nedergaard BS;Ladekarl M;Thomsen HF;Nyengaard JR;Nielsen K
通讯作者：
Nielsen K
影响因子：
56.9
作者：
Ishikawa, Kaori;Takenaga, Keizo;Hayashi, Jun-Ichi
通讯作者：
Hayashi, Jun-Ichi
影响因子：
45.3
作者：
Jensen, Hanne Krogh;Donskov, Frede;von der Maase, Hans
通讯作者：
von der Maase, Hans
DOI：
10.3324/haematol.2010.031542
发表时间：
2011-02-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Kamper, Peter;Bendix, Knud;d'Amore, Francesco
通讯作者：
d'Amore, Francesco
影响因子：
4.7
作者：
Lee, Yoo-Young;Choi, Chel Hun;Bae, Duk-Soo
通讯作者：
Bae, Duk-Soo