Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment.
Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment.
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肠道微生物群和血浆胆汁酸的分析可以对患者进行分层以进行抗糖尿病治疗
DOI：
10.1038/s41467-017-01682-2
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发表时间：
2017-11-27
影响因子：
16.6
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Gu Y;Wang X;Li J;Zhang Y;Zhong H;Liu R;Zhang D;Feng Q;Xie X;Hong J;Ren H;Liu W;Ma J;Su Q;Zhang H;Yang J;Wang X;Zhao X;Gu W;Bi Y;Peng Y;Xu X;Xia H;Li F;Xu X;Yang H;Xu G;Madsen L;Kristiansen K;Ning G;Wang W
抗糖尿病药物可以调节肠道微生物群，从而改变血浆和粪便胆汁酸（BA）组成，这可能改善代谢健康。在这里，我们表明，阿卡波糖治疗，而不是格列吡嗪，增加原发性BA和继发性BA之间的比例和未结合的BA的血浆水平在治疗初治的2型糖尿病（T2D）患者，这可能会有益地影响代谢。阿卡波糖增加了肠道微生物群中乳酸杆菌和双歧杆菌的相对丰度，并减少了拟杆菌，从而改变了参与BA代谢的微生物基因的相对丰度。阿卡波糖的治疗结果取决于治疗前的肠道微生物群组成。与肠道菌群以普雷沃菌为主的患者相比，阿卡波糖治疗后，类杆菌丰度高的患者血浆BA变化更多，代谢参数改善更大。我们的工作强调了在治疗前根据肠道微生物群对T2D患者进行分层的可能性。
Antidiabetic medication may modulate the gut microbiota and thereby alter plasma and faecal bile acid (BA) composition, which may improve metabolic health. Here we show that treatment with Acarbose, but not Glipizide, increases the ratio between primary BAs and secondary BAs and plasma levels of unconjugated BAs in treatment-naive type 2 diabetes (T2D) patients, which may beneficially affect metabolism. Acarbose increases the relative abundances ofLactobacillusandBifidobacteriumin the gut microbiota and depletesBacteroides, thereby changing the relative abundance of microbial genes involved in BA metabolism. Treatment outcomes of Acarbose are dependent on gut microbiota compositions prior to treatment. Compared to patients with a gut microbiota dominated byPrevotella, those with a high abundance ofBacteroidesexhibit more changes in plasma BAs and greater improvement in metabolic parameters after Acarbose treatment. Our work highlights the potential for stratification of T2D patients based on their gut microbiota prior to treatment.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/s0889-8529(05)70266-8
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