In vivo hyperpolarization transfer in a clinical MRI scanner.
In vivo hyperpolarization transfer in a clinical MRI scanner.
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DOI：
10.1002/mrm.27154
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发表时间：
2018-08
影响因子：
3.3
通讯作者：
Merritt ME
中科院分区：
文献类型：
--
作者：
von Morze C;Reed GD;Larson PE;Mammoli D;Chen AP;Tropp J;Van Criekinge M;Ohliger MA;Kurhanewicz J;Vigneron DB;Merritt ME
本研究的目的是在临床磁共振成像（MRI）扫描仪中探究体内13C - > 1H超极化转移的可行性，这对于检测超极化13C探针的分布和代谢具有显著的潜在优势。
开发了一个独立的脉冲13C射频发射通道，以便与临床3T MRI扫描仪的标准1H通道协同工作。在外部硬件上编写了用于13C功率校准和极化转移的脉冲序列，并与在扫描仪上并行运行的定制水抑制1H磁共振波谱（MRS）采集相结合。新开发的射频系统在1JCH耦合系统中进行了体模和体内极化转移实验测试：在热极化和超极化（HP）[2 - 13C]甘油中的体模实验，以及在大鼠体内肝脏中对由超极化[2 - 13C]丙酮酸产生的[2 - 13C]乳酸进行1H检测。
定制脉冲13C射频通道的运行实现了有效的13C - > 1H超极化转移，这通过1H检测到的、1JCH耦合的双峰的特征性反相外观得到了证实。结合在体内提供190倍水抑制的脉冲序列，在大鼠肝脏切片中实现了对体内产生的超极化[2 - 13C]乳酸的1H检测。
结果表明，在具有定制异核射频系统的临床MRI扫描仪中进行有效的13C - > 1H超极化转移具有明显的可行性。
The purpose of this study was to investigate the feasibility of in vivo 13C->1H hyperpolarization transfer, which has significant potential advantages for detecting the distribution and metabolism of hyperpolarized 13C probes, in a clinical MRI scanner. A standalone pulsed 13C RF transmit channel was developed for operation in conjunction with the standard 1H channel of a clinical 3T MRI scanner. Pulse sequences for 13C power calibration and polarization transfer were programmed on the external hardware and integrated with a customized water-suppressed 1H MRS acquisition running in parallel on the scanner. The newly developed RF system was tested in both phantom and in vivo polarization transfer experiments in 1JCH-coupled systems: phantom experiments in thermally polarized and HP [2-13C]glycerol, and 1H detection of [2-13C]lactate generated from HP [2-13C]pyruvate in rat liver in vivo. Operation of the custom pulsed 13C RF channel resulted in effective 13C->1H hyperpolarization transfer, as confirmed by the characteristic anti-phase appearance of 1H-detected, 1JCH-coupled doublets. In conjunction with a pulse sequence providing 190-fold water suppression in vivo, 1H detection of HP [2-13C]lactate generated in vivo was achieved in a rat liver slice. The results show clear feasibility for effective 13C->1H hyperpolarization transfer in a clinical MRI scanner with customized heteronuclear RF system.
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影响因子：
3.3
作者：
Sodickson, DK;Manning, WJ
通讯作者：
Manning, WJ
影响因子：
3.3
作者：
Hurd, Ralph E.;Spielman, Daniel;Josan, Sonal;Yen, Yi-Fen;Pfefferbaum, Adolf;Mayer, Dirk
通讯作者：
Mayer, Dirk
影响因子：
2.2
作者：
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通讯作者：
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影响因子：
2.9
作者：
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通讯作者：
Skloss, Timothy W.
影响因子：
82.9
作者：
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通讯作者：
Brindle, Kevin M.