The endocytic pathways of Dictyostelium discoideum.

The endocytic pathways of Dictyostelium discoideum.
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盘基网柄菌的内吞途径。

DOI:
--
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发表时间:
2019
影响因子:
0.7
通讯作者:
J. King
J. King
中科院分区:
生物学4区
文献类型:
--
作者:
James H Vines;J. King

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从细胞表面形成和加工囊泡提供许多重要的细胞功能,从营养获取到调节膜组分和信号传导的周转。在这篇文章中,我们总结了内吞途径的社会阿米巴Dictyosteelium从网格蛋白依赖和独立的内化的表面成分的吞噬和巨胞饮作用的细菌或液体的吞噬作用。由于与哺乳动物免疫系统的专职吞噬细胞的相似性,网囊藻已被广泛用于研究吞噬体和巨胞饮体通过细胞时发生的复杂重塑和运输事件。在这里,我们讨论了什么是已知的这个成熟过程,以杀死任何潜在的病原体,并获得生长所需的营养。最后,我们的目标是把这些研究在进化的背景下,并强调一些仍然在我们的理解这些复杂和重要的途径的许多问题。
The formation and processing of vesicles from the cell surface serves many important cellular functions ranging from nutrient acquisition to regulating the turnover of membrane components and signalling. In this article, we summarise the endocytic pathways of the social amoeba Dictyostelium from the clathrin-dependent and independent internalisation of surface components to the engulfment of bacteria or fluid by phagocytosis and macropinocytosis respectively. Due to similarities with the professional phagocytes of the mammalian immune system Dictyostelium has been extensively used to investigate the complex remodelling and trafficking events that occur as phagosomes and macropinosomes transit through the cell. Here we discuss what is known about this maturation process in order to kill any potential pathogens and obtain nutrients for growth. Finally, we aim to put these studies in evolutionary context and highlight some of the many questions that remain in our understanding of these complex and important pathways.
以汤为生:阿米巴原虫的巨胞饮摄食。
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