Sense of meaning and purpose in life and risk of incident dementia: New data and meta-analysis.
Sense of meaning and purpose in life and risk of incident dementia: New data and meta-analysis.
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DOI：
10.1016/j.archger.2022.104847
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发表时间：
2023-02
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
生活中更大的意义和目的感与较低的痴呆症风险有关。本研究在迄今为止最大的样本中检查了意义和痴呆事件，英国生物银行，并将研究结果与已发表的关于意义/目的和痴呆风险的文献进行了荟萃分析。来自英国生物银行的参与者在2016/2017年心理健康评估中报告了他们的生活意义（N= 153，445）。全因和病因特异性痴呆症来自截至2021年11月的医院和死亡记录。考克斯回归被用来检验生活意义和痴呆症发病风险之间的关系。在随机效应荟萃分析中，将英国生物样本库的结果与通过系统性文献综述确定的已发表研究相结合（k=8;总N= 214，270）。英国生物库参与者在评估生命意义后接受了长达五年的随访; 551名参与者患上了痴呆症。意义感每增加一分，全因痴呆的风险就降低35%（HR= 0.74，95%CI = 0.67 - 0.82，p<0.001）。控制临床和行为危险因素后，这种关联是相似的，并且不受年龄、性别、教育或APOE风险状态的影响。阿尔茨海默病和血管性痴呆也有类似的联系。荟萃分析支持意义/目的与较低痴呆风险之间的保护性关联（HR= 0.76，95%CI = 0.72 - 0.79，p<0.001）。目前的研究支持了越来越多的文献，即生活的意义和目的与患痴呆症的风险较低有很强的关联。意义/目的是老年人健康认知结果的一个有前途的干预目标。
A greater sense of meaning and purpose in life is associated with lower dementia risk. The present research examines meaning and incident dementia in the largest sample to date, the UK Biobank, and combines the findings with the published literature on meaning/purpose and dementia risk in a meta-analysis. Participants from the UK Biobank reported on their meaning in life in the 2016/2017 mental health assessment (N=153,445). All-cause and cause-specific dementia were derived from hospital and death records through November 2021. Cox regression was used to test the association between meaning in life and risk of incident dementia. Results from the UK Biobank were combined with published studies identified through a systematic literature review in a random-effect meta-analysis (k=8; total N=214,270). UK Biobank participants were followed up to five years after their assessment of meaning in life; 551 participants developed dementia. For every one-point higher feeling of meaning, there was a 35% decreased risk of all-cause dementia (HR=.74, 95% CI=.67-.82, p<.001). The association was similar controlling for clinical and behavioral risk factors and was not moderated by age, sex, education, or APOE risk status. Similar associations were found for Alzheimer’s disease and vascular dementia. The meta-analysis supported the protective association between meaning/purpose and lower dementia risk (HR=.76, 95% CI=.72-.79, p<.001). The present research supports the growing literature that meaning and purpose in life have a robust association with lower risk of developing dementia. Meaning/purpose is a promising intervention target for healthier cognitive outcomes in older adulthood.
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影响因子：
4.7
作者：
Sutin, Angelina R.;Luchetti, Martina;Terracciano, Antonio
通讯作者：
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作者：
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