Manual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury.
Manual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury.
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DOI：
10.3389/fphys.2021.755923
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发表时间：
2021
影响因子：
4
通讯作者：
Bove GM
中科院分区：
文献类型：
--
作者：
Barbe MF;Panibatla ST;Harris MY;Amin M;Dorotan JT;Cruz GE;Bove GM
背景：由于多种原因，由重复性职业工作引起的重复性劳损难以预防。因此，我们研究了休息的手动治疗（MT）治疗通过执行重复性任务而发展的炎症和纤维化的有效性。我们假设，这种治疗将减少任务引起的感觉运动下降和神经肌肉炎症。方法：29只雌性SD大鼠进行了为期14周的伸手和拉弓任务。所有人都在14周时停止执行任务。在该时间点（任务）对10只动物实施人道处死。9名患者在休息7周（MTR）时接受上肢手法治疗; 10名患者被分配为单独休息（REST）。纳入了另外10只既不执行任务也不接受手动治疗（FRC）的限食大鼠。结果如下：重复先前的实验，ASK大鼠表现出行为变化（前爪机械超敏反应、握力降低、前肢/前爪敏捷性降低和有害冷温度敏感性）、正中神经传导速度（NCV）降低和病理组织变化（髓磷脂降解、正中神经和肌肉炎症增加和胶原蛋白产生）。休息的手动治疗（MTR）改善了REST大鼠的冷敏感性，增强了肌肉白细胞介素10（IL-10）比REST大鼠，导致大多数其他措施的改善，与ASK大鼠相比。与ASK大鼠相比，REST大鼠显示握力改善，神经炎症降低，髓鞘降解，肌肉肿瘤坏死因子α（TNFα）和胶原蛋白I水平降低，但前肢/前爪敏捷性和NCV仍降低，神经纤维化增加。结论：在我们的重复性运动障碍模型中，与单独休息相比，休息期间的手动治疗对行为、组织学和生理学指标有适度的影响。这些发现与在同一模型中手动治疗的强大预防作用形成对比。
Background: Repetitive strain injuries caused by repetitive occupational work are difficult to prevent for multiple reasons. Therefore, we examined the effectiveness of manual therapy (MT) with rest to treat the inflammation and fibrosis that develops through the performance of a repetitive task. We hypothesized that this treatment would reduce task-induced sensorimotor declines and neuromuscular inflammation. Methods: Twenty-nine female Sprague-Dawley rats performed a reaching and lever-pulling task for 14weeks. All ceased performing the task at 14weeks. Ten were euthanized at this timepoint (TASK). Nine received manual therapy to their upper extremities while resting 7weeks (MTR); 10 were assigned to rest alone (REST). Ten additional food restricted rats were included that neither performed the task nor received manual therapy (FRC). Results: Confirming previous experiments, TASK rats showed behavioral changes (forepaw mechanical hypersensitivity, reduced grip strength, lowered forelimb/forepaw agility, and noxious cold temperature sensitivity), reduced median nerve conduction velocity (NCV), and pathological tissue changes (myelin degradation, increased median nerve and muscle inflammation, and collagen production). Manual therapy with rest (MTR) ameliorated cold sensitivity seen in REST rats, enhanced muscle interleukin 10 (IL-10) more than in REST rats, lead to improvement in most other measures, compared to TASK rats. REST rats showed improved grip strength, lowered nerve inflammation and degraded myelin, and lowered muscle tumor necrosis factor alpha (TNFα) and collagen I levels, compared to TASK rats, yet maintained lowered forelimb/forepaw agility and NCV, and increased neural fibrosis. Conclusion: In our model of repetitive motion disorder, manual therapy during rest had modest effects on behavioral, histological, and physiological measures, compared to rest alone. These findings stand in contrast to the robust preventive effects of manual therapy in this same model.
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影响因子：
2.7
作者：
Benjamini, Yoav;Krieger, Abba M.;Yekutieli, Daniel
通讯作者：
Yekutieli, Daniel
影响因子：
3.5
作者：
BORG, K;LINDBLOM, U
通讯作者：
LINDBLOM, U
影响因子：
2.3
作者：
Barbe MF;Harris MY;Cruz GE;Amin M;Billett NM;Dorotan JT;Day EP;Kim SY;Bove GM
通讯作者：
Bove GM
DOI：
10.1002/jor.24709
发表时间：
2020-11
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Barbe MF;Hilliard BA;Amin M;Harris MY;Hobson LJ;Cruz GE;Dorotan JT;Paul RW;Klyne DM;Popoff SN
通讯作者：
Popoff SN
影响因子：
2.3
作者：
Barbe MF;Gallagher S;Massicotte VS;Tytell M;Popoff SN;Barr-Gillespie AE
通讯作者：
Barr-Gillespie AE