Key indicators of repetitive overuse-induced neuromuscular inflammation and fibrosis are prevented by manual therapy in a rat model.
Key indicators of repetitive overuse-induced neuromuscular inflammation and fibrosis are prevented by manual therapy in a rat model.
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DOI：
10.1186/s12891-021-04270-0
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发表时间：
2021-05-05
影响因子：
2.3
通讯作者：
Bove GM
中科院分区：
文献类型：
--
作者：
Barbe MF;Harris MY;Cruz GE;Amin M;Billett NM;Dorotan JT;Day EP;Kim SY;Bove GM
我们研究了由前臂皮肤滚动，肌肉动员和上肢牵引组成的手动治疗的有效性，作为对执行密集的拉筋任务的大鼠的预防性治疗。我们假设，这种治疗将减少任务引起的神经肌肉和肌腱炎症，纤维化和感觉运动下降。Sprague-Dawley大鼠进行了达到和杠杆拉动任务的食物奖励，2小时/天，3天/周，持续12周，同时接受手动治疗治疗，每周3次，持续12周，无论是任务涉及的上肢（任务-Tx），或下肢作为主动对照组（任务-Ac）。将结果与类似处理的对照大鼠（C-Tx和C-Ac）进行比较。与TASK-Tx大鼠相比，TASK-Ac大鼠的正中神经和前臂屈肌肌肉和肌腱显示出更高数量的炎性CD 68+和致纤维化CD 206+巨噬细胞，特别是在神经外膜、肌内膜和肌腱外膜中。TASK-Tx大鼠中的CD 68+和CD 206+巨噬细胞数量与非任务对照组相当。与TASK-Tx大鼠相比，TASK-Ac大鼠具有更多的正中神经纤维化、I型前胶原蛋白水平和屈指肌中的免疫表达以及屈指肌腱外膜中的纤维化变化（其显示出与对照组相当的反应）。TASK-Ac大鼠表现出寒冷的温度、较低的反射性握力和任务回避，这些反应在TASK-Tx大鼠中未观察到（其表现出与对照组相当的反应）。参与执行伸手和抓握任务的前肢的手动治疗防止了前臂神经、肌肉和肌腱的炎症和纤维化变化以及感觉运动下降的发展。在线版本包含补充材料，可通过10.1186/s12891-021-04270-0获得。
We examined the effectiveness of a manual therapy consisting of forearm skin rolling, muscle mobilization, and upper extremity traction as a preventive treatment for rats performing an intensive lever-pulling task. We hypothesized that this treatment would reduce task-induced neuromuscular and tendon inflammation, fibrosis, and sensorimotor declines. Sprague-Dawley rats performed a reaching and lever pulling task for a food reward, 2 h/day, 3 days/week, for 12 weeks, while simultaneously receiving the manual therapy treatment 3 times per week for 12 weeks to either the task-involved upper extremities (TASK-Tx), or the lower extremities as an active control group (TASK-Ac). Results were compared to similarly treated control rats (C-Tx and C-Ac). Median nerves and forearm flexor muscles and tendons of TASK-Ac rats showed higher numbers of inflammatory CD68+ and fibrogenic CD206+ macrophages, particularly in epineurium, endomysium and epitendons than TASK-Tx rats. CD68+ and CD206+ macrophages numbers in TASK-Tx rats were comparable to the non-task control groups. TASK-Ac rats had more extraneural fibrosis in median nerves, pro-collagen type I levels and immunoexpression in flexor digitorum muscles, and fibrogenic changes in flexor digitorum epitendons, than TASK-Tx rats (which showed comparable responses as control groups). TASK-Ac rats showed cold temperature, lower reflexive grip strength, and task avoidance, responses not seen in TASK-Tx rats (which showed comparable responses as the control groups). Manual therapy of forelimbs involved in performing the reaching and grasping task prevented the development of inflammatory and fibrogenic changes in forearm nerves, muscle, and tendons, and sensorimotor declines. The online version contains supplementary material available at 10.1186/s12891-021-04270-0.
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影响因子：
4.1
作者：
Butterfield TA;Zhao Y;Agarwal S;Haq F;Best TM
通讯作者：
Best TM
拉伸会影响结缔组织的炎症分辨率。
影响因子：
5.6
作者：
Berrueta L;Muskaj I;Olenich S;Butler T;Badger GJ;Colas RA;Spite M;Serhan CN;Langevin HM
通讯作者：
Langevin HM
DOI：
10.1016/j.jmpt.2012.06.002
发表时间：
2012-07-01
影响因子：
1.3
作者：
De-la-Llave-Rincon, Ana I.;Ortega-Santiago, Ricardo;Fernandez-de-las-Penas, Cesar
通讯作者：
Fernandez-de-las-Penas, Cesar
影响因子：
--
作者：
Brandt C;Pedersen BK
通讯作者：
Pedersen BK
DOI：
10.1002/jor.24709
发表时间：
2020-11
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Barbe MF;Hilliard BA;Amin M;Harris MY;Hobson LJ;Cruz GE;Dorotan JT;Paul RW;Klyne DM;Popoff SN
通讯作者：
Popoff SN