Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension.
Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension.
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DOI：
10.3389/fnins.2021.690919
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发表时间：
2021
影响因子：
4.3
通讯作者：
Zubcevic J
中科院分区：
文献类型：
--
作者：
Donertas Ayaz B;Oliveira AC;Malphurs WL;Redler T;de Araujo AM;Sharma RK;Sirmagul B;Zubcevic J
硫化氢（H2S）是一种具有神经调节、抗炎和抗高血压作用的气体信号分子。在这里，我们研究了氢硫化钠（NaHS），一种H2S供体，是否可以缓解血管紧张素II （Ang II）诱导的高血压（HTN），改善自主神经功能，并影响下丘脑室旁核（PVN）的小胶质细胞，下丘脑室旁核是与自主控制血压（BP）和HTN神经炎症相关的大脑区域。长期给药（200 ng/kg/min，皮下）4周后，雄性sd大鼠PVN中钙离子结合受体分子1阳性（Iba1+）细胞数量增加，血压和交感神经驱动明显升高。在ICV中同时输注NaHS（30和/或60 nmol/h）可显著减弱Ang II的这些作用。在30和60 nmol/h浓度下，ICV NaHS共注入可抑制Ang II增加盲肠Deltaproteobacteria和Desulfovibrionales等细菌的丰度。我们观察到各组之间循环H2S没有差异。我们的研究结果表明，中枢H2S可能通过对自主神经系统和PVN小胶质细胞的影响而独立于循环H2S缓解啮齿动物HTN。
Hydrogen sulfide (H2S) is a gaseous signaling molecule with neuromodulatory, anti-inflammatory, and anti-hypertensive effects. Here, we investigate whether chronic intracerebroventricular (ICV) infusion of sodium hydrosulfide (NaHS), an H2S donor, can alleviate angiotensin II (Ang II)–induced hypertension (HTN), improve autonomic function, and impact microglia in the paraventricular nucleus (PVN) of the hypothalamus, a brain region associated with autonomic control of blood pressure (BP) and neuroinflammation in HTN. Chronic delivery of Ang II (200 ng/kg/min, subcutaneous) for 4 weeks produced a typical increase in BP and sympathetic drive and elevated the number of ionized calcium binding adaptor molecule 1–positive (Iba1+) cells in the PVN of male, Sprague–Dawley rats. ICV co-infusion of NaHS (at 30 and/or 60 nmol/h) significantly attenuated these effects of Ang II. Ang II also increased the abundance of cecal Deltaproteobacteria and Desulfovibrionales, among others, which was prevented by ICV NaHS co-infusion at 30 and 60 nmol/h. We observed no differences in circulating H2S between the groups. Our results suggest that central H2S may alleviate rodent HTN independently from circulating H2S via effects on autonomic nervous system and PVN microglia.
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