The Role of Gaseous Molecules in Traumatic Brain Injury: An Updated Review.
The Role of Gaseous Molecules in Traumatic Brain Injury: An Updated Review.
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气体分子在创伤性脑损伤中的作用：最新综述
DOI：
10.3389/fnins.2018.00392
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发表时间：
2018
影响因子：
4.3
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Che X;Fang Y;Si X;Wang J;Hu X;Reis C;Chen S
在中国，创伤性脑损伤（TBI）每年影响数百万人。创伤性脑损伤死亡率高，往往预后严重。创伤性脑损伤在发展和恢复过程中的致病机制仍然不明确，这给医学界提供改善预后和提供最佳恢复的治疗方案带来了挑战。生物气体分子包括一氧化氮（NO）、一氧化碳（CO）、硫化氢（H2S）和分子氢（H2），在哺乳动物的生理和病理状态中起着至关重要的作用。越来越多的证据表明，这些气体分子可以在许多中枢神经系统（CNS）条件下执行神经保护，因为它们的高渗透性允许它们进入大脑。考虑到创伤性脑损伤复杂的发病机制和严重的预后，迫切需要有效和适当的治疗方法。这四种气体分子可能是潜在的有吸引力的创伤性脑损伤治疗干预措施。在这篇综述中，我们将全面介绍这四种生物气体在TBI发展中的作用及其潜在的治疗应用。
Traumatic brain injury (TBI) affects millions of people in China each year. TBI has a high mortality and often times a serious prognosis. The causative mechanisms of TBI during development and recovery from an injury remain vague, leaving challenges for the medical community to provide treatment options that improve prognosis and provide an optimal recovery. Biological gaseous molecules including nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S), and molecular hydrogen (H2) have been found to play critical roles in physiological and pathological conditions in mammals. Accumulating evidence has found that these gaseous molecules can execute neuroprotection in many central nervous system (CNS) conditions due to their highly permeable properties allowing them to enter the brain. Considering the complicated mechanisms and the serious prognosis of TBI, effective and adequate therapeutic approaches are urgently needed. These four gaseous molecules can be potential attractive therapeutic intervention on TBI. In this review, we will present a comprehensive overview on the role of these four biological gasses in the development of TBI and their potential therapeutic applications.
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DOI：
10.1152/ajpheart.00091.2003
发表时间：
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影响因子：
4.8
作者：
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