Low-level subchronic exposure to wood smoke exacerbates inflammatory responses in allergic rats.
Low-level subchronic exposure to wood smoke exacerbates inflammatory responses in allergic rats.
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低水平亚慢性暴露于木烟会加剧过敏大鼠的炎症反应。
DOI：
10.1093/toxsci/kfi317
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Mauderly,JoeL
中科院分区：
文献类型：
--
作者：
Tesfaigzi,Yohannes;McDonald,JacobD;Reed,MatthewD;Singh,ShashibhushanP;DeSanctis,GeorgeT;Eynott,PaulR;Hahn,FletcherF;Campen,MatthewJ;Mauderly,JoeL
流行病学研究表明，木材烟雾是加剧哮喘的一个危险因素。然而，目前无法将动物模型中的结果与人类中的结果进行比较，因为在动物研究中无法获得肺功能的详细临床相关测量结果。用卵清蛋白免疫Brown Norway大鼠，将其暴露于1 mg颗粒物/m3的过滤空气或木材烟雾中70 d，并在暴露的最后4 d用变应原进行攻击。与暴露于过滤空气的大鼠相比，暴露于木材烟雾的大鼠动态肺顺应性的基线值较低，而功能残气量增加。与对照组相比，暴露于木材烟雾的大鼠支气管肺泡灌洗液和血浆中IFN-γ水平降低，IL-4水平升高，肺部炎症病变增加21%，气道粘液细胞/mm基底层无显著增加。总的来说，这些研究表明，大鼠的肺功能受到木材烟雾暴露的影响，这种下降仅与肺部炎症的轻微增加有关。因此，该动物模型可能有助于阐明环境污染物致哮喘患者肺功能下降的机制。
Epidemiological studies have implicated wood smoke as a risk factor for exacerbating asthma. However, comparisons of findings in animal models with those in humans are currently not possible, because detailed clinically relevant measurements of pulmonary function are not available in animal studies. Brown Norway rats were immunized with ovalbumin and exposed to either filtered air or wood smoke at 1 mg particulate matter/m3for 70 days and challenged with allergen during the last 4 days of exposure. Baseline values for dynamic lung compliance were lower while functional residual capacity was increased in rats exposed to wood smoke compared to rats exposed to filtered air. IFN-γ levels were reduced and IL-4 levels increased in the bronchoalveolar lavage fluid and blood plasma, inflammatory lesions in the lungs were 21% greater, and airway mucous cells/mm basal lamina were non-significantly increased in rats exposed to wood smoke compared to controls. Collectively, these studies suggest that the pulmonary function was affected in rats by exposure to wood smoke and this decline was associated with only minor increases in inflammation of the lung. Therefore, this animal model may be useful to elucidate the mechanisms of the decline in pulmonary function caused by environmental pollutants when asthmatics are exposed to allergen.
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人嗜酸性粒细胞表达和产生 CXC 趋化因子生长相关癌基因-α1
影响因子：
4.4
作者：
Terese Persson;Pia Andersson;A. Bjartell;J. Calafat;A. Egesten
通讯作者：
A. Egesten
DOI：
10.1165/ajrcmb.26.4.4473
发表时间：
2002-04-01
影响因子：
6.4
作者：
Fischer, BM;Voynow, JA
通讯作者：
Voynow, JA
Bcl-2 在 LPS 和过敏原诱导的布朗挪威大鼠气道上皮增生粘液细胞中。
DOI：
10.1152/ajplung.2000.279.6.l1210
发表时间：
2000
期刊：
American journal of physiology. Lung cellular and molecular physiology
影响因子：
--
作者：
Tesfaigzi,Y;Fischer,MJ;Martin,AJ;Seagrave,J
通讯作者：
Seagrave,J
影响因子：
2.2
作者：
Carson, RT;Vignali, DAA
通讯作者：
Vignali, DAA
影响因子：
8.3
作者：
KOENIG, JQ;LARSON, TV;PIERSON, WE
通讯作者：
PIERSON, WE