Edge modification facilitated heterogenization and exfoliation of two-dimensional nanomaterials for cancer catalytic therapy.
Edge modification facilitated heterogenization and exfoliation of two-dimensional nanomaterials for cancer catalytic therapy.
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DOI：
10.1126/sciadv.abo7372
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发表时间：
2022-09-30
期刊：
影响因子：
13.6
通讯作者：
中科院分区：
文献类型：
--
作者：
电子-空穴对的快速复合和有限的底物是限制催化治疗效果的最关键因素。因此，制备了二维面间异质结（BiOCl/Bi 2 O3），其延长了激发电子和空穴的寿命，并在超声照射下扩展了衬底的选择性，以促进高性能的癌症治疗。边缘修改提出了边缘BiOCl取代Bi 2 O3构建面间异质结，促进由于增强的边缘亲和力与H2O的nanosheets剥离。自发排列的费米能级介导了内置的电场引导的Z方案平面间异质结，延迟电子空穴对复合，并提高氧化还原电位。因此，这些高能电子和空穴能够催化多种稳定的底物，例如还原反应，O2 → ·O2−和CO2 → CO，以及氧化反应，GSH → GSSG和H2O → ·OH。Z型面间异质结具有扩展的底物选择性，完全打破了肿瘤微环境的限制，表现出较高的抗癌活性。Z型平面异质结具有两个活性中心，催化四种氧化还原反应，用于癌症催化治疗。
The rapid recombination of electron-hole pairs and limited substrates are the most critical factors astricting the effect of catalytic therapy. Thus, two-dimensional interplanar heterojunction (BiOCl/Bi2O3) that prolongs the lifetime of excited electrons and holes and extends the selectivity of substrates under ultrasound irradiation is prepared to facilitate high-performance cancer therapy. An edge modification displacing marginal BiOCl to Bi2O3 is proposed to construct the interplanar heterojunction, promoting ultrathin nanosheets exfoliation due to the enhanced edge affinity with H2O. The spontaneously aligning Fermi levels mediate a built-in electric field–guided Z-scheme interplanar heterojunction, retard electron-hole pairs recombination, and improve redox potentials. Hence, these high-powered electrons and holes are capable of catalyzing diverse and stable substrates, such as the reduction reactions, O2 → ·O2− and CO2 → CO, and oxidation reactions, GSH → GSSG and H2O → ·OH. The Z-scheme interplanar heterojunction with the extending substrates selectivity completely breaks the tumor microenvironment limitation, exhibiting high anticancer activity. The Z-scheme interplanar heterojunction has two active centers to catalyze four redox reactions for cancer catalytic therapy.
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