Dorsomedial hypothalamic lesions counteract decreases in locomotor activity in male Syrian hamsters transferred from long to short day lengths.
Dorsomedial hypothalamic lesions counteract decreases in locomotor activity in male Syrian hamsters transferred from long to short day lengths.
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DOI：
10.1177/0748730414561546
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发表时间：
2015-02
影响因子：
3.5
通讯作者：
Zucker I
中科院分区：
文献类型：
--
作者：
Jarjisian SG;Butler MP;Paul MJ;Place NJ;Prendergast BJ;Kriegsfeld LJ;Zucker I
下丘脑的背内侧核（DMN）与生殖的季节性控制有关。与对照仓鼠不同，DMN病变的叙利亚仓鼠在从长日照（每天14小时光照; LD）转移到短日照（每天8小时光照; SD）后不会发生睾丸退化。SD还显著降低仓鼠运动活性（LMA）。为了评估DMN是否是介导LMA季节性变化的神经回路的组成部分，将神经系统完整的雄性（对照）和具有DMN（DMNx）持续病变的仓鼠在LD或SD光周期中饲养26周。在8 - 10周SD治疗期间，DMNx可防止睾丸退化，抵消LMA的降低; SD的类固醇非依赖性效应并未覆盖DMNx男性中高水平的LMA。与先前的研究一样，睾酮（T）恢复增加了LD而非SD去势对照雄性的LMA。在本研究中，T也未能增加SD-DMNx仓鼠中的LMA。DMN是不必要的，以维持降低的运动活动系统的反应性，以T在SD，这大概是介导的其他中枢神经系统雄激素靶组织。最后，DMNx不干扰光不应性仓鼠在SD治疗26周后表现出的LMA自发增加。我们建议，DMN是一个重要组成部分的基板，介导的季节性下降，在LMA日长减少，但不需要维持降低SD的反应T或发展的耐火性SD。
The dorsomedial nucleus (DMN) of the hypothalamus has been implicated in seasonal control of reproduction. Syrian hamsters with DMN lesions, unlike control hamsters, do not undergo testicular regression after transfer from a long day length (14 h of light per day; LD) to a short day length (8 h of light per day; SD). SDs also markedly reduce hamster locomotor activity (LMA). To assess whether the DMN is a component of the neural circuitry that mediates seasonal variation in LMA, neurologically intact males (controls) and hamsters that had sustained lesions of the DMN (DMNx) were housed in an LD or SD photoperiod for 26 weeks. DMNx that prevented testicular regression counteracted decreases in LMA during 8 to10 weeks of SD treatment; steroid-independent effects of SDs did not override high levels of LMA in DMNx males. As in previous studies, testosterone (T) restoration increased LMA in LD but not SD castrated control males. In the present study, T also failed to increase LMA in SD-DMNx hamsters. The DMN is not necessary to maintain decreased responsiveness of locomotor activity systems to T in SDs, which presumably is mediated by other central nervous system androgen target tissues. Finally, DMNx did not interfere with the spontaneous increase in LMA exhibited by photorefractory hamsters after 26 weeks of SD treatment. We propose that DMN is an essential part of the substrate that mediates seasonal decreases in LMA as day length decreases but is not required to sustain decreased SD responsiveness to T or for development of refractoriness to SDs.
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影响因子：
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