Measuring the lung function in the mouse: the challenge of size.
Measuring the lung function in the mouse: the challenge of size.
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DOI：
10.1186/rr199
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发表时间：
2003
影响因子：
5.8
通讯作者：
Bates JH
中科院分区：
文献类型：
--
作者：
Irvin CG;Bates JH
测量药物、介质和感染因子对各种肺部疾病模型的影响，以及评估完整小鼠的肺功能，有可能显著提高我们对肺部疾病的认识。然而，小鼠的小尺寸对肺功能的评估提出了重大挑战。由于精确性和非侵入性之间的妥协，获得的数据可能对肺的机械反应有不确定的影响。尽管如此，最近在开发有效和有用的小鼠肺功能测量方法方面取得了相当大的进展。这些进步，使我们目前能够测量实验动物肺功能的复杂指标，可能会导致对肺部疾病机制的重要见解。
Measurement of the effects of drugs, mediators and infectious agents on various models of lung disease, as well as assessment of lung function in the intact mouse has the potential for significantly advancing our knowledge of lung disease. However, the small size of the mouse presents significant challenges for the assessment of lung function. Because of compromises made between precision and noninvasiveness, data obtained may have an uncertain bearing on the mechanical response of the lung. Nevertheless, considerable recent progress has been made in developing valid and useful measures of mouse lung function. These advances, resulting in our current ability to measure sophisticated indices of lung function in laboratory animals, are likely to lead to important insights into the mechanisms of lung disease.
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DOI：
10.1164/ajrccm.162.3.9910100
发表时间：
2000-09-01
影响因子：
24.7
作者：
Kanehiro, A;Takeda, K;Gelfand, EW
通讯作者：
Gelfand, EW
影响因子：
3.3
作者：
LEVITT, RC;MITZNER, W
通讯作者：
MITZNER, W
影响因子：
4.8
作者：
LEVITT, RC;MITZNER, W
通讯作者：
MITZNER, W
影响因子：
56.9
作者：
Finotto, S;Neurath, MF;Glimcher, LH
通讯作者：
Glimcher, LH
影响因子：
3.3
作者：
Bates, JHT;Irvin, CG
通讯作者：
Irvin, CG