Region of interest analysis: by selecting regions with denuded areas can we detect greater amounts of change?
Region of interest analysis: by selecting regions with denuded areas can we detect greater amounts of change?
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DOI：
10.1016/j.joca.2009.08.002
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发表时间：
2010-02
影响因子：
7
通讯作者：
Beals, C. R.
中科院分区：
文献类型：
--
作者：
Hunter, D. J.;Li, L.;Zhang, Y. Q.;Totterman, S.;Tamez, J.;Kwoh, C. K.;Eaton, C. B.;Le Graverand, M. -P. Hellio;Beals, C. R.
基于最近的分析，MRI衍生软骨形态测量的短期反应性的测量可能不像早期研究所建议的那么大。我们检查了通过选择具有裸露软骨的感兴趣区域，该感兴趣区域内的剩余软骨是否对更大的软骨损失率敏感。纳入本分析的受试者是骨关节炎倡议（OAI）研究中约4700名参与者的一个子集。在基线时和每年获得所有参与者的双侧X线片和3 T MRI（Siemens Trio）以及临床数据。来自OAI进展子队列的150例受试者，根据在OAI诊所进行的筛选阅读，所有受试者均具有常见症状，并且在同一膝关节中具有放射学骨关节炎（罗阿定义为X线上明确的胫骨-股骨骨赘）。选择每例受试者的一个膝关节进行分析。使用基线和12个月随访访视的矢状面3D DESSwe MR图像，将分割算法应用于索引膝关节的软骨板，以计算软骨体积、标准化软骨体积（体积标准化为骨表面界面面积）和裸露面积百分比（软骨裸露的总软骨骨界面面积）。计算第1年较基线变化（绝对值和百分比）的汇总统计量和标准化反应均值（SRM），即平均变化除以该变化的标准差。根据裸露面积的基线评估，将分析分为三组：基线时感兴趣区域无裸露面积的组，然后是样本量相等的2组（中度裸露面积（≤中位数）和重度（>中位数）裸露面积）。受试者平均年龄为60.9岁，肥胖，平均BMI为30.3 kg/m2。对于股骨和胫骨中央内侧组合，整个样本的平均体积变化为−48.2（SD 159.8）mm 3，其SRM为−0.30。在无裸露区的膝关节子样本中，SRM为-0.25，在中度裸露区的膝关节中，SRM为-0.30，在重度裸露区的膝关节中，SRM为-1.00。对于股骨中央内侧的标准化体积，在无裸露区的膝关节子样本中，SRM为-0.22，在中度裸露区的膝关节中，SRM为-0.26，在重度裸露区的膝关节（n=23）中，SRM为-0.71。在没有裸露区的参与者中，SRMs的大小通常较小。相反，裸露区参与者的SRMs较大。结论：通过选择存在具有裸露区域的软骨区域的参与者，与在该软骨板中没有全层损伤的人相比，证明该特定位置中软骨损失变化的能力显著提高。这种在临床试验招募期间进行筛查的选择可以帮助检测出后续软骨丢失风险更大的参与者。
Based on recent analyses, the measures of short-term responsiveness of MRI derived cartilage morphometry may not be as large as earlier studies had suggested. We examined if by selecting regions of interest with denuded cartilage, if the remaining cartilage within this region of interest was susceptible to greater rates of cartilage loss. Subjects included for this analysis are a subset of the approximately 4700 participants in the Osteoarthritis Initiative (OAI) Study. Bilateral radiographs and 3T MRI (Siemens Trio) of the knees and clinical data are obtained at baseline and annually in all participants.150 subjects from the OAI Progression subcohort all of whom had both frequent symptoms and, in the same knee, radiographic osteoarthritis (ROA defined as definite tibio-femoral osteophytes on x-ray) based on a screening reading done at the OAI clinics. One knee from each subject was selected for analysis. Using sagittal 3D DESSwe MR images from the baseline and 12 follow-up month visit, a segmentation algorithm was applied to the cartilage plates of the index knee to compute the cartilage volume, normalized cartilage volume (Volume normalized to bone surface interface area), and percent denuded area (Total Cartilage Bone Interface area denuded of cartilage). Summary statistics of the changes (absolute and percentage) from baseline at one year and the standardized response mean (SRM), i.e. mean change divided by the standard deviation of that change were calculated. Analyses are stratified into three groups according to baseline assessment of denuded area: those with no denuded area in the region of interest at baseline, and then 2 groups (intermediate denuded area (≤median) and severe (> median) denuded area) of equal sample size. On average the subjects were 60.9 years of age and obese with a mean BMI of 30.3 kg/m2. For the combined central medial femur and tibia the mean volume change for the whole sample was −48.2 (SD 159.8) mm3, which gives an SRM of−0.30. In the subsample of knees with no denuded area the SRM was −0.25, in the knees with intermediate denuded area the SRM was −0.30, and in knees with severe denuded area the SRM was -1.00. For normalized volume of the central medial femur in the subsample of knees with no denuded area the SRM was −0.22, in the knees with intermediate denuded area the SRM was −0.26, and in knees with severe denuded area (n=23) the SRM was −0.71. The magnitude of the SRMs was generally smaller in participants with no denuded area. In contrast, the SRMs in participants with denuded area were larger. CONCLUSION: By selecting participants with the presence of cartilage regions with denuded area the ability to demonstrate change in cartilage loss in that specific location is markedly improved compared to persons without a full thickness lesion in that cartilage plate. This option for screening during recruitment in clinical trials could facilitate the detection of participants at greater risk of subsequent cartilage loss.
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影响因子：
27.4
作者：
Hunter, D. J.;Niu, J.;Beals, C. R.
通讯作者：
Beals, C. R.
影响因子：
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作者：
Garnero, P;Ayral, X;Delmas, PD
通讯作者：
Delmas, PD
影响因子：
7
作者：
Hunter, D. J.;Conaghan, P. G.;Genant, H. K.
通讯作者：
Genant, H. K.
影响因子：
7
作者：
Calvo, E;Palacios, I;Herrero-Beaumont, G
通讯作者：
Herrero-Beaumont, G
影响因子：
27.4
作者：
Hunter, D. J.;Niu, J. B.;Felson, D. T.
通讯作者：
Felson, D. T.