In vivo detection of citrate in brain tumors by 1H magnetic resonance spectroscopy at 3T.
In vivo detection of citrate in brain tumors by 1H magnetic resonance spectroscopy at 3T.
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DOI：
10.1002/mrm.24946
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发表时间：
2014-08
影响因子：
3.3
通讯作者：
Maher, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Choi, Changho;Ganji, Sandeep K.;Madan, Akshay;Hulsey, Keith M.;An, Zhongxu;Zhang, Song;Pinho, Marco C.;DeBerardinis, Ralph J.;Bachoo, Robert M.;Maher, Elizabeth A.
使用 3T 体内 1H MRS 测试成年神经胶质瘤患者的柠檬酸盐是否升高。 34 名成年患者参与了这项研究，其中包括 6 名胶质母细胞瘤受试者、8 名星形细胞瘤受试者（5 名 WHO 3 级和 3 名 2 级）和 20 名少突胶质细胞瘤受试者（5 名 3 级和 15 名 2 级）。研究了五名健康志愿者的基线柠檬酸盐数据。使用 PRESS TE = 35 和 97 ms 收集单体素局部光谱，并使用 LCModel 使用数值计算的基础光谱进行分析，其中包括 PRESS 射频和梯度脉冲的影响。健康大脑中的 MRS 无法测量柠檬酸盐，但在肿瘤患者的两个回波时间均检测到柠檬酸盐。参考 42 M 的水，柠檬酸盐浓度估计高达 1.8 mM，CRLB 低至 5%。平均柠檬酸盐水平为 0.7±0.4 mM（平均值±SD，n=32），中位 CRLB 约为 12%。柠檬酸盐浓度与肿瘤分级或组织学类型之间没有发现相关性。大多数成年神经胶质瘤患者的柠檬酸盐含量增加。我们的数据中柠檬酸盐升高表明肿瘤相对于健康大脑的代谢状态发生了变化。
To test whether the citrate is elevated in adult patients with gliomas using 1H MRS at 3T in vivo. Thirty-four adult patients were enrolled in the study, including 6 subjects with glioblastomas, 8 subjects with astrocytomas (5 WHO grade-3 and 3 grade-2), and 20 subjects with oligodendrogliomas (5 grade-3 and 15 grade-2). Five healthy volunteers were studied for baseline citrate data. Single-voxel localized spectra were collected with PRESS TE = 35 and 97 ms and analyzed with LCModel using numerically calculated basis spectra that include the effects of the PRESS radio-frequency and gradient pulses. Citrate was not measurable by MRS in healthy brain, but was detected in tumor patients at both echo times. The citrate concentration was estimated to be as high as 1.8 mM with reference to water at 42 M, with CRLB as low as 5%. The mean citrate level was 0.7±0.4 mM (mean±SD, n=32) with median CRLB of ~12%. No correlation was identified between citrate concentration and tumor grade or histological type. Citrate was increased in the majority of gliomas in adult patients. The elevated citrate in our data indicates an altered metabolic state of tumor relative to healthy brain.
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影响因子：
37.3
作者：
Wright AJ;Fellows GA;Griffiths JR;Wilson M;Bell BA;Howe FA
通讯作者：
Howe FA
影响因子：
3.3
作者：
GRUETTER, R
通讯作者：
GRUETTER, R
影响因子：
3.5
作者：
Seymour, Z. A.;Panigrahy, A.;Bluml, S.
通讯作者：
Bluml, S.
影响因子：
3.3
作者：
Scheenen, TWJ;Gambarota, G;Heerschap, A
通讯作者：
Heerschap, A
影响因子：
2.9
作者：
Choi, Changho;Dimitrov, Ivan E.;Maher, Elizabeth A.
通讯作者：
Maher, Elizabeth A.