Stem cell dynamics in response to nutrient availability.
Stem cell dynamics in response to nutrient availability.
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DOI：
10.1016/j.cub.2010.10.038
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发表时间：
2010-12-07
期刊：
影响因子：
9.2
通讯作者：
Jones, D. Leanne
中科院分区：
文献类型：
--
作者：
McLeod, Catherine J.;Wang, Lei;Wong, Chihunt;Jones, D. Leanne
当营养供应变得有限时，动物必须积极调整新陈代谢以分配有限的资源并维持组织稳态。然而，人们对成体干细胞维持的组织如何响应新陈代谢的慢性变化知之甚少。为了开始解决这个问题，我们给果蝇喂食缺乏蛋白质（蛋白质饥饿）的饮食，并分析了种系干细胞和肠道干细胞。我们的结果显示干细胞增殖减少，干细胞数量减少；然而，仍然存在一小部分活性干细胞。重新喂养后，干细胞数量急剧增加，表明剩余的干细胞有能力对营养状况的变化做出快速反应。干细胞的维持严重依赖于调节干细胞行为的内在和外在因素。生殖系干细胞和邻近支持细胞中胰岛素/IGF信号（IIS）途径的激活足以抑制饥饿期间干细胞的损失。因此，我们的数据表明干细胞可以直接感知全身环境的变化，以协调其行为与动物的营养状况，为代谢应激下维持组织稳态提供范例。
When nutrient availability becomes limited, animals must actively adjust their metabolism to allocate limited resources and maintain tissue homeostasis. However, it is poorly understood how tissues maintained by adult stem cells respond to chronic changes in metabolism. To begin to address this question, we fed flies a diet lacking protein (protein starvation) and assayed both germline and intestinal stem cells. Our results revealed a decrease in stem cell proliferation and a reduction in stem cell number; however, a small pool of active stem cells remained. Upon re-feeding, stem cell number increased dramatically, indicating that the remaining stem cells are competent to respond quickly to changes in nutritional status. Stem cell maintenance is critically dependent upon intrinsic and extrinsic factors that act to regulate stem cell behaviour. Activation of the insulin/IGF signalling (IIS) pathway in stem cells and adjacent support cells in the germ line was sufficient to suppress stem cell loss during starvation. Therefore, our data indicate that stem cells can directly sense changes in the systemic environment to coordinate their behaviour with the nutritional status of the animal, providing a paradigm for maintaining tissue homeostasis under metabolic stress.
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影响因子：
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作者：
Biteau B;Karpac J;Supoyo S;Degennaro M;Lehmann R;Jasper H
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DOI：
10.1073/pnas.0809144106
发表时间：
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