URG4 overexpression is correlated with cervical cancer progression and poor prognosis in patients with early-stage cervical cancer.
URG4 overexpression is correlated with cervical cancer progression and poor prognosis in patients with early-stage cervical cancer.
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URG4过表达与早期宫颈癌患者的宫颈癌进展和不良预后相关
DOI：
10.1186/1471-2407-14-885
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发表时间：
2014-11-26
期刊：
影响因子：
3.8
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Zhang L;Huang H;Zhang L;Hou T;Wu S;Huang Q;Song L;Liu J
背景细胞增殖上调因子 4 (URG4) 与某些癌症的发生有关。然而，URG4 表达与人类癌症临床病理意义之间的相关性仍不清楚。因此，本研究探讨了其在宫颈癌患者中的表达及其临床病理意义。方法采用定量PCR（qPCR）和蛋白质印迹法检测URG4在正常宫颈上皮细胞、宫颈癌细胞以及来自同一患者的8对匹配的宫颈癌组织和癌旁非癌组织中的表达。此外，使用免疫组织化学 (IHC) 检测 167 名宫颈癌患者（FIGO 分期 Ib1-IIa2）石蜡包埋组织中 URG4 的表达。进行统计分析以评估URG4表达与预后和诊断因素之间的关联。结果与正常细胞和邻近非癌性宫颈组织相比，URG4在宫颈癌细胞系和组织中显着上调。 IHC 显示 167 份宫颈癌标本中有 59 份 (35.13%) 存在高 URG4 表达。其表达与临床分期（P< 0.0001）、肿瘤大小（P= 0.012）、T分型（P= 0.023）、淋巴结转移（P= 0.001）和阴道受累（P= 0.002）显着相关。与该蛋白低表达的患者相比，URG4高表达的患者，特别是接受同步化疗和放疗的患者（P<0.0001），显示出较短的总生存期（OS）和无病生存期（DFS）。多变量分析显示URG4表达是宫颈癌患者的独立预后因素。结论我们的结果表明URG4蛋白表达升高与早期宫颈癌患者的不良预后相关。 URG4可能成为宫颈癌治疗的新型预后标志物和治疗靶点。
BackgroundUpregulator of cell proliferation 4 (URG4) has been implicated in the oncogenesis of certain cancers. However, the correlation between URG4 expression and clinicopathological significance in human cancer remains unclear. Therefore, this study investigated its expression and clinicopathological significance in cervical cancer patients.MethodsURG4 expression was examined using quantitative PCR (qPCR) and western blotting in normal cervical epithelial cells, cervical cancer cells, and eight matched pairs of cervical cancer tissues and adjacent noncancerous tissues from the same patient. In addition, immunohistochemistry (IHC) was used to examine URG4 expression in paraffin-embedded tissues from 167 cervical cancer patients (FIGO stages Ib1-IIa2). Statistical analyses were performed to evaluate associations between URG4 expression and prognostic and diagnostic factors.ResultsURG4 was significantly upregulated in the cervical cancer cell lines and tissues compared with the normal cells and adjacent noncancerous cervical tissues. IHC revealed high URG4 expression in 59 out of the 167 (35.13%) cervical cancer specimens. Its expression was significantly correlated with clinical stage (P< 0.0001), tumour size (P= 0.012), T classification (P= 0.023), lymph node metastasis (P= 0.001) and vaginal involvement (P= 0.002). Patients with high URG4 expression, particularly those who received concurrent chemotherapy and radiotherapy (P< 0.0001), showed a shorter overall survival (OS) and disease-free survival (DFS) compared to those with the low expression of this protein. Multivariate analysis revealed that URG4 expression is an independent prognostic factor for cervical cancer patients.ConclusionsOur results demonstrated that elevated URG4 protein expression is associated with a poor outcome in patients with early-stage cervical cancer. URG4 may be a novel prognostic marker and therapeutic target for the treatment of cervical cancer.
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Sam68表达及胞质定位与早期宫颈癌患者淋巴结转移及预后相关
影响因子：
50.5
作者：
Li, Z.;Yu, C. -P.;Song, L. -B.
通讯作者：
Song, L. -B.
DOI：
10.1056/nejmoa1309748
发表时间：
2014-02-20
期刊：
The New England journal of medicine
影响因子：
--
作者：
Tewari KS;Sill MW;Long HJ 3rd;Penson RT;Huang H;Ramondetta LM;Landrum LM;Oaknin A;Reid TJ;Leitao MM;Michael HE;Monk BJ
通讯作者：
Monk BJ
影响因子：
2.8
作者：
Dodurga, Yavuz;Avci, Cigir Biray;Gunduz, Cumhur
通讯作者：
Gunduz, Cumhur
新基因URG4增强胃癌细胞的存活率
影响因子：
4.8
作者：
Song, Jiugang;Xie, Huahong;Fan, Daiming
通讯作者：
Fan, Daiming
DOI：
10.1016/s0301-2115(96)02637-1
发表时间：
1997-02-01
期刊：
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
影响因子：
--
作者：
Pickel, H;Haas, J;Lahousen, M
通讯作者：
Lahousen, M