Passive exposure to agricultural pesticides and risk of childhood leukemia in an Italian community.
Passive exposure to agricultural pesticides and risk of childhood leukemia in an Italian community.
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DOI：
10.1016/j.ijheh.2016.09.015
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发表时间：
2016-11
影响因子：
6
通讯作者：
Vinceti, Marco
中科院分区：
文献类型：
--
作者：
Malagoli, Carlotta;Costanzini, Sofia;Heck, Julia E.;Malavolti, Marcella;De Girolamo, Gianfranco;Oleari, Paola;Palazzi, Giovanni;Teggi, Sergio;Vinceti, Marco
Exposure to pesticides has been suggested as a risk factor for childhood leukemia, but definitive evidence on this relation and the specific pesticides involved is still not clear. We carried out a population-based case-control study in a Northern Italy community to assess the possible relation between passive exposure to agricultural pesticides and risk of acute childhood leukemia. We assessed passive pesticide exposure of 111 childhood leukemia cases and 444 matched controls by determining density and type of agricultural land use within a 100-m radius buffer around children’s homes. We focused on four common crop types, arable, orchard, vineyard and vegetable, characterized by the use of specific pesticides that are potentially involved in childhood induced leukemia. The use of these pesticides was validated within the present study. We computed the odds ratios (OR) of the disease and their 95% confidence intervals (CI) according to type and density of crops around the children’s homes, also taking into account traffic pollution and high-voltage power line magnetic field exposure. Childhood leukemia risk did not increase in relation with any of the crop types with the exception of arable crops, characterized by the use of 2.4-D, MCPA, glyphosate, dicamba, triazine and cypermethrin. The very few children (n=11) residing close to arable crops had an OR for childhood leukemia of 2.04 (95% CI 0.50–8.35), and such excess risk was further enhanced among children aged < 5 years. Despite the null association with most crop types and the statistical imprecision of the estimates, the increased leukemia risk among children residing close to arable crops indicates the need to further investigate the involvement in disease etiology of passive exposure to herbicides and pyrethroids, though such exposure is unlikely to play a role in the vast majority of cases.
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影响因子：
10.4
作者：
Fenske RA;Lu C;Barr D;Needham L
通讯作者：
Needham L
影响因子：
10.4
作者：
Gunier RB;Ward MH;Airola M;Bell EM;Colt J;Nishioka M;Buffler PA;Reynolds P;Rull RP;Hertz A;Metayer C;Nuckols JR
通讯作者：
Nuckols JR
DOI：
10.1038/sj.jea.7500348
发表时间：
2005-01-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Freeman, NCG;Hore, P;Lioy, PJ
通讯作者：
Lioy, PJ
影响因子：
6.4
作者：
Bailey, Helen D.;Infante-Rivard, Claire;Schuez, Joachim
通讯作者：
Schuez, Joachim
DOI：
10.1080/10590501.2015.1002999
发表时间：
2015
期刊：
Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews
影响因子：
--
作者：
Filippini T;Heck JE;Malagoli C;Del Giovane C;Vinceti M
通讯作者：
Vinceti M