Sensitivity of a fentanyl-vs.-social interaction choice procedure to environmental and pharmacological manipulations.
Sensitivity of a fentanyl-vs.-social interaction choice procedure to environmental and pharmacological manipulations.
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DOI：
10.1016/j.pbb.2022.173473
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发表时间：
2022-11
影响因子：
3.6
通讯作者：
Townsend, E. Andrew
中科院分区：
文献类型：
--
作者：
Onge, Celsey M. St.;Taylor, Kaia M.;Marcus, Madison M.;Townsend, E. Andrew
最近的研究表明，在大鼠的选择环境下，社交互动可以作为阿片类药物自我给药的替代强化剂。然而，需要额外的参数研究来评估阿片类药物与社会互动程序相对于更成熟的阿片类药物与食品程序的敏感性。目前的研究评估了一种新型芬太尼与社会互动选择程序对环境和药理学操作的敏感性，此前研究表明这些操作会影响芬太尼与食物的选择。雄性和雌性大鼠（应答大鼠；n=6/性别）经过训练，在离散试验选择程序中做出反应，要么在 30 秒内接触同性“伴侣”大鼠，要么静脉注射芬太尼。经过训练后，在数周内确定芬太尼单位剂量（0、0.32–10 μg/kg/inf）、伙伴大鼠的存在、阿片类药物依赖状态、长期纳曲酮给药（0.032、0.1 mg/kg/h）以及芬太尼自我给药的反应要求（固定比例1–320）的效果。芬太尼与社会互动的选择程序对芬太尼的单位剂量、长期纳曲酮治疗和芬太尼反应要求敏感。然而，这些对芬太尼选择的影响程度小于已发表的芬太尼与食物选择研究中报告的影响程度。此外，芬太尼与社会互动的选择对伴侣大鼠的消除或阿片类药物依赖状态不敏感。检测到最小的性别差异。这些结果表明，与先前建立的阿片类药物与食物选择程序相比，芬太尼与社会互动选择程序对环境和药理学干预的敏感性较低。观察到的程序之间的敏感性差异表明，与更常见评估的替代强化物（例如食物（临床前）或金钱（人类实验室））相比，社交互动可能具有质上不同的强化特性。
Recent studies have shown that social interaction can serve as an alternative reinforcer to opioid self-administration under a choice context in rats. However, additional parametric studies are needed to evaluate the sensitivity of opioid-vs.-social interaction procedures relative to more established opioid-vs.-food procedures. The current study evaluated the sensitivity of a novel fentanyl-vs.-social interaction choice procedure to environmental and pharmacological manipulations previously shown to affect fentanyl-vs.-food choice. Male and female rats (responder rats; n=6/sex) were trained to respond in a discrete-trial choice procedure for either 30-s access to a same-sex “partner” rat or an intravenous fentanyl infusion. Once trained, the effects of fentanyl unit dose (0, 0.32–10 μg/kg/inf), partner rat presence, opioid-dependence status, chronic naltrexone administration (0.032, 0.1 mg/kg/h), and response requirement for fentanyl self-administration (fixed ratio 1–320) were determined across weeks. The fentanyl-vs.-social interaction choice procedure was sensitive to the unit dose of fentanyl, chronic naltrexone treatment, and fentanyl response requirement. However, the magnitude of these effects on fentanyl choice was smaller than those reported in published fentanyl-vs.-food choice studies. Furthermore, fentanyl-vs.-social interaction choice was not sensitive to removal of the partner rat or opioid-dependence status. Minimal sex differences were detected. These results suggest that this fentanyl-vs.-social interaction choice procedure is less sensitive to environmental and pharmacological interventions than previously established opioid-vs.-food choice procedures. The observed discrepancy in sensitivity between the procedures suggests that social interaction may have qualitatively different reinforcing properties compared to more commonly assessed alternative reinforcers such as food (preclinical) or money (human laboratory).
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影响因子：
4.7
作者：
Heyman GM
通讯作者：
Heyman GM
影响因子：
3.4
作者：
Baldwin, A. N.;Banks, M. L.;Marsh, S. A.;Townsend, E. A.;Venniro, M.;Shaham, Y.;Negus, S. Stevens
通讯作者：
Negus, S. Stevens
影响因子：
10.6
作者：
Venniro M;Russell TI;Zhang M;Shaham Y
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Shaham Y
影响因子：
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作者：
Vandaele, Youna;Cantin, Lauriane;Ahmed, Serge H.
通讯作者：
Ahmed, Serge H.
影响因子：
4.2
作者：
Chow JJ;Beckmann JS
通讯作者：
Beckmann JS