Remifentanil-food choice follows predictions of relative subjective value.
Remifentanil-food choice follows predictions of relative subjective value.
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DOI：
10.1016/j.drugalcdep.2020.108369
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发表时间：
2021-01-01
影响因子：
4.2
通讯作者：
Beckmann JS
中科院分区：
文献类型：
--
作者：
Chow JJ;Beckmann JS
关于药物选择与非药物选择的临床前研究已经出现，以更好地模拟和研究药物偏好背后的神经行为机制。目前的文献表明，滥用药物的价值天生就很低，从而促进了人们对食物的偏好。在这里，我们研究了瑞芬太尼与食物选择的对比，以检验阿片类药物偏好的相对值假说和直接效应假说(药物对替代增强剂的药理效应)。成年雄性大鼠在两种选择程序(受控和非受控强化频率)下接受瑞芬太尼和食物选择的训练。此外，已知会影响药物强化的一系列程序操作在两种选择程序下都进行了测试。使用瑞芬太尼自身给药数据，计算和分析药代动力学曲线，以确定阿片类药物摄入量是否与阿片类药物偏好有关。这两种选择程序都产生了剂量依赖的偏好。此外，在两种选择程序中，程序操作在瑞芬太尼偏好方面产生了类似的变化。此外，计算的药代动力学数据显示，在受控的增强剂频率选择程序下，偏好与摄入量是分离的。与“直接效应”假说相比，瑞芬太尼偏好更好地由相对值假说来预测，该假说在广义匹配中被形式化。使用受控的增强剂频率计划成功地消除了在大多数药物选择程序中发现的药物偏好-摄取混淆。重要的是，受控增强剂频率计划下的药物偏好仍然对已知的影响药物强化的程序操作敏感。因此，考虑到不同的药物摄入量本身会影响神经生物学测量，未来使用受控的增强剂频率时间表可能有助于更好地分离调节阿片类药物偏好的神经行为机制。
Preclinical studies into drug vs. nondrug choice have emerged to better model and investigate the neurobehavioral mechanisms underlying drug preference. Current literature has suggested that drugs of abuse have inherently low value, thus promoting food preference. Herein, we examined remifentanil vs. food choice to test both the relative value hypothesis and the ‘direct effects’ (pharmacological effects of drugs on alternative reinforcers) hypothesis of opioid preference. Adult male rats were trained under two choice procedures (controlled vs. uncontrolled reinforcer frequency) for remifentanil vs. food choice. Furthermore, a series of procedural manipulations known to affect drug reinforcement were tested under both choice procedures. Using remifentanil self-administration data, pharmacokinetic profiles were calculated and analyzed to determine if opioid intake was related to opioid preference. Both choice procedures produced dose-dependent preference. Moreover, procedural manipulations produced comparable changes in remifentanil preference under both choice procedures. In addition, calculated pharmacokinetic data revealed that preference was dissociable from intake under the controlled reinforcer frequency choice procedure. When compared to the ‘direct effects’ hypothesis, remifentanil preference was better predicted by the relative value hypothesis, formalized in generalized matching. Use of a controlled reinforcer frequency schedule successfully removed the drug preference-intake confound found in most drug-choice procedures. Importantly, drug preference under the controlled reinforcer frequency schedule remained sensitive to procedural manipulations known to affect drug reinforcement. Thus, given that differential drug intake itself affects neurobiological measurements, future use of controlled reinforcer frequency schedules may help to better isolate the neurobehavioral mechanisms that mediate opioid preference.
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影响因子：
4.7
作者：
Heyman GM
通讯作者：
Heyman GM
影响因子：
7.6
作者：
Alsop, Brent;Furukawa, Emi;Tripp, Gail
通讯作者：
Tripp, Gail
影响因子：
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作者：
Cantin, Lauriane;Lenoir, Magalie;Ahmed, Serge H.
通讯作者：
Ahmed, Serge H.
影响因子：
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作者：
Comer SD;Metz VE;Cooper ZD;Kowalczyk WJ;Jones JD;Sullivan MA;Manubay JM;Vosburg SK;Smith ME;Peyser D;Saccone PA
通讯作者：
Saccone PA
影响因子：
13.9
作者：
Hyman, Steven E.;Malenka, Robert C.;Nestler, Eric J.
通讯作者：
Nestler, Eric J.