Gene expression patterns in pancreatic tumors, cells and tissues.
Gene expression patterns in pancreatic tumors, cells and tissues.
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DOI：
10.1371/journal.pone.0000323
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发表时间：
2007-03-28
期刊：
影响因子：
3.7
通讯作者：
Brown PO
中科院分区：
文献类型：
--
作者：
Lowe AW;Olsen M;Hao Y;Lee SP;Taek Lee K;Chen X;van de Rijn M;Brown PO
胰腺的癌症起源于该器官的内分泌和外分泌因素，是癌症相关死亡的主要原因。本研究对胰腺肿瘤、正常胰腺和非肿瘤性胰腺疾病的基因表达进行了全面评估。DNA微阵列用于评估手术源性胰腺腺癌、胰岛细胞肿瘤和间质肿瘤的基因表达。正常胰腺、离体胰岛、离体胰管和胰腺腺癌细胞系的加入通过增加获得的基因表达谱的多样性来增强后续分析。外分泌、内分泌和间质肿瘤显示出独特的基因表达谱。基因表达的相似性支持胰管作为腺癌的起源。此外，在胰腺肿瘤中也发现了在其他癌症中高表达并与特定信号转导途径相关的基因。目前工作的范围通过纳入公开可用的数据集而得到增强，这些数据集涵盖了广泛的人体组织，并能够识别可能服务于诊断和治疗目标的候选基因。
Cancers of the pancreas originate from both the endocrine and exocrine elements of the organ, and represent a major cause of cancer-related death. This study provides a comprehensive assessment of gene expression for pancreatic tumors, the normal pancreas, and nonneoplastic pancreatic disease. DNA microarrays were used to assess the gene expression for surgically derived pancreatic adenocarcinomas, islet cell tumors, and mesenchymal tumors. The addition of normal pancreata, isolated islets, isolated pancreatic ducts, and pancreatic adenocarcinoma cell lines enhanced subsequent analysis by increasing the diversity in gene expression profiles obtained. Exocrine, endocrine, and mesenchymal tumors displayed unique gene expression profiles. Similarities in gene expression support the pancreatic duct as the origin of adenocarcinomas. In addition, genes highly expressed in other cancers and associated with specific signal transduction pathways were also found in pancreatic tumors. The scope of the present work was enhanced by the inclusion of publicly available datasets that encompass a wide spectrum of human tissues and enabled the identification of candidate genes that may serve diagnostic and therapeutic goals.
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影响因子：
5.3
作者：
Lustig, B;Jerchow, B;Behrens, J
通讯作者：
Behrens, J
影响因子：
3.3
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Chen, X;Cheung, ST;Brown, PO
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Brown, PO
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3.7
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8.8
作者：
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通讯作者：
Neoptolemos, JP
影响因子：
64.8
作者：
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通讯作者：
Staudt, LM