Mechanisms of circadian clock interactions with aryl hydrocarbon receptor signalling.
Mechanisms of circadian clock interactions with aryl hydrocarbon receptor signalling.
复制标题
昼夜节律与芳基烃受体信号传导相互作用的机制。
DOI：
10.1111/ejn.14361
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发表时间：
2020-01
影响因子：
3.4
通讯作者：
Tischkau, Shelley A.
中科院分区：
文献类型：
--
作者：
Tischkau, Shelley A.
含Per - Arnt - Sim（PAS）结构域的蛋白质对稳态调节网络至关重要，该网络介导对环境变化的响应。PAS结构域是多功能的结构基序，允许家族成员之间发生蛋白质 - 蛋白质相互作用，通常形成异二聚体转录因子以影响靶基因的转录。典型的依赖PAS结构域的通路包括生物钟网络以及通过芳香烃受体（AhR）对外源物质反应的代谢调节。这两种通路与健康的联系日益紧密，其功能的改变会导致疾病的发生。芳香烃受体（AhR）在配体结合和异二聚体形成过程中的选择性方面表现出混杂性，这使得它与其他含Per - Arnt - Sim（PAS）结构域的蛋白质之间有多种蛋白质/蛋白质相互作用组合，并在包括生物钟机制在内的信号通路之间产生串扰。AhR和生物钟信号通路高度整合且相互调节。AhR呈现出节律性表达，并且对AhR激动剂激活的敏感性具有时间依赖性。相反，AhR影响生物钟基因、激素和行为的节律幅度和相位。了解AhR和生物钟之间的分子相互作用有助于深入了解节律过程的生理调节，并为开发治疗方法提供一种创新途径。
Per-Arnt-Sim (PAS) domain-containing proteins are critical to homeostatic regulatory networks that mediate responsiveness to environmental change. PAS domains are multifunctional structural motifs that allow protein-protein interactions among family members, typically forming heterodimeric transcription factors to affect the transcription of target genes. Prototypical PAS domain-dependent pathways include the circadian clock network and metabolic regulation of the xenobiotic response through the aryl hydrocarbon receptor (AhR). Both pathways are increasingly linked to health, and alteration in their function contributes to development of disease. The aryl hydrocarbon receptor (AhR) demonstrates promiscuity in ligand binding and selectivity during heterodimer formation, which allows varied combinations of protein/protein interactions with other Per-Arnt-Sim (PAS) domain containing proteins and crosstalk among signaling pathways, including the molecular clockworks. AhR and the circadian signaling pathways are highly integrated and reciprocally regulated. AhR exhibits a rhythmic expression and time-dependent sensitivity to activation by AhR agonists. Conversely, AhR influences amplitude and phase of rhythms in circadian clock genes, hormones, and behavior. Understanding the molecular interactions between AhR and the clock provides insight into physiological regulation of rhythmic processes and provides an innovative approach to development of therapeutics.
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影响因子：
64.8
作者：
Cheng, MY;Bullock, CM;Zhou, QY
通讯作者：
Zhou, QY
影响因子：
3.4
作者：
Buijs, RM;Wortel, J;Kalsbeek, A
通讯作者：
Kalsbeek, A
DOI：
10.1073/pnas.96.23.13468
发表时间：
1999-11-09
影响因子：
11.1
作者：
Chen, D;Buchanan, GF;Gillette, MU
通讯作者：
Gillette, MU
影响因子：
5.6
作者：
Arble, Deanna M.;Bass, Joseph;Wright, Kenneth P.
通讯作者：
Wright, Kenneth P.
影响因子：
4.8
作者：
Baba, T;Mimura, J;Fujii-Kuriyama, Y
通讯作者：
Fujii-Kuriyama, Y