The Mycobiome: Cancer Pathogenesis, Diagnosis, and Therapy.
The Mycobiome: Cancer Pathogenesis, Diagnosis, and Therapy.
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DOI：
10.3390/cancers14122875
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发表时间：
2022-06-10
期刊：
影响因子：
5.2
通讯作者：
Ghannoum, Mahmoud
中科院分区：
文献类型：
--
作者：
Gamal, Ahmed;Elshaer, Mohammed;Alabdely, Mayyadah;Kadry, Ahmed;McCormick, Thomas S.;Ghannoum, Mahmoud
在过去的几十年里，微生物组在健康和疾病中的作用得到了极大的关注。证明微生物群和癌症之间联系的证据一直在增加。尽管有几项研究已经探索了这个主题，但他们的主要关注点一直是细菌，而忽略了微生物组中另一个重要的组：真菌。最近的研究表明，细菌和真菌之间存在着复杂的相互作用。此外，已发表的数据表明，真菌菌群在几种癌症的发展中具有重要作用，例如马拉色菌和胰腺癌之间的联系。此外，与单一群落分析相比，同时研究细菌和真菌显示出更多的信息。类似地，细菌体和真菌菌体调节对现有抗癌治疗的有效性和耐受性有显著的积极影响。因此，微生物组研究还应包括其他微生物群落，如真菌。癌症是全球主要的死亡原因之一。尽管癌症研究取得了进展，但对确切原因的充分了解尚未确定。最近的数据表明，微生物组与癌症在各个层面上都有重要的关系，包括癌症的发病机制、诊断和预后以及治疗。由于大多数研究只关注细菌在这一过程中的作用，在本文中，我们回顾了真菌--微生物组的另一个重要类别，其全部被称为“真菌组”--在癌症发展中的作用，以及它如何影响抗癌药物的反应。此外，我们提供了最近的证据，表明不同的微生物群落如何在胃肠道和非胃肠道部位(包括皮肤)相互作用和影响，从而强调了研究细菌以外的微生物群的重要性。
The role of the microbiome in health and disease has gained great attention over the past few decades. The evidence demonstrating the link between the microbiome and cancer has been growing. Although several studies have explored this topic, their main focus has been on bacteria, ignoring another important group in the microbiome: fungi. Recent studies have demonstrated the complex interactions between bacteria and fungi inhabiting the human body. Furthermore, published data show that the mycobiome has a significant role in the development of several cancers, such as the link between Malassezia and pancreatic duct adenocarcinoma. Additionally, studying bacteria and fungi together was shown to be more informative compared to single community analysis. Similarly, bacteriome and mycobiome modulation have significant positive effects on the efficacy and tolerability of the available anticancer therapies. Thus, microbiome studies should also include other microbial communities, such as fungi. Cancer is among the leading causes of death globally. Despite advances in cancer research, a full understanding of the exact cause has not been established. Recent data have shown that the microbiome has an important relationship with cancer on various levels, including cancer pathogenesis, diagnosis and prognosis, and treatment. Since most studies have focused only on the role of bacteria in this process, in this article we review the role of fungi—another important group of the microbiome, the totality of which is referred to as the “mycobiome”—in the development of cancer and how it can impact responses to anticancer medications. Furthermore, we provide recent evidence that shows how the different microbial communities interact and affect each other at gastrointestinal and non-gastrointestinal sites, including the skin, thereby emphasizing the importance of investigating the microbiome beyond bacteria.
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影响因子：
29.4
作者：
Chen X;Fruehauf J;Goldsmith JD;Xu H;Katchar KK;Koon HW;Zhao D;Kokkotou EG;Pothoulakis C;Kelly CP
通讯作者：
Kelly CP
影响因子：
4.6
作者：
Banerjee S;Tian T;Wei Z;Peck KN;Shih N;Chalian AA;O'Malley BW;Weinstein GS;Feldman MD;Alwine J;Robertson ES
通讯作者：
Robertson ES
影响因子：
3.7
作者：
Chan AS;Jonas AB;Qiu X;Ottoson NR;Walsh RM;Gorden KB;Harrison B;Maimonis PJ;Leonardo SM;Ertelt KE;Danielson ME;Michel KS;Nelson M;Graff JR;Patchen ML;Bose N
通讯作者：
Bose N
影响因子：
20.3
作者：
Beelen, DW;Elmaagacli, A;Schaefer, UW
通讯作者：
Schaefer, UW
影响因子：
9
作者：
Banerjee S;Wei Z;Tian T;Bose D;Shih NNC;Feldman MD;Khoury T;De Michele A;Robertson ES
通讯作者：
Robertson ES