Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness.
Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness.
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意识障碍患者失配负性的空间特性
DOI：
10.1007/s12264-018-0260-4
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发表时间：
2018-08
影响因子：
5.6
通讯作者：
Cong F
中科院分区：
文献类型：
--
作者：
Wang X;Fu R;Xia X;Chen X;Wu H;Landi N;Pugh K;He J;Cong F
近几十年来，事件相关电位已被用于意识障碍（DOC）患者的临床电生理评估。在本文中，采用两种频率偏差刺激（标准刺激为 1000 Hz 纯音；小偏差刺激为 1050 Hz 纯音；大偏差刺激为 1200 Hz 纯音）的奇怪范例，在 30 名使用 JFK 昏迷恢复量表修订版诊断为 DOC 的患者中引发失配负性 (MMN) （CRS-R）。结果表明，大的和小的异常刺激引起的 MMN 峰值幅度与基线显着不同。就 MMN 的空间特性而言，条件（小和大的异常刺激）和电极节点之间的显着交互作用集中在额中央区域。此外，还计算了所有参与者每个电极的 MMN 振幅和 CRS-R 评分之间的相关系数，以生成地形图。同时，在额中央区域也发现由大的异常刺激引起的MMN振幅与CRS-R评分之间存在显着的负相关。因此，我们的结果结合了 DOC 患者 MMN 的上述空间特性，并提供了更精确的位置（额中央区域）来评估临床电生理评估与意识水平之间的相关性。
In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness (DOCs). In this paper, an oddball paradigm with two types of frequency-deviant stimulus (standard stimuli were pure tones of 1000 Hz; small deviant stimuli were pure tones of 1050 Hz; large deviant stimuli were pure tones of 1200 Hz) was applied to elicit mismatch negativity (MMN) in 30 patients with DOCs diagnosed using the JFK Coma Recovery Scale-Revised (CRS-R). The results showed that the peak amplitudes of MMN elicited by both large and small deviant stimuli were significantly different from baseline. In terms of the spatial properties of MMN, a significant interaction effect between conditions (small and large deviant stimuli) and electrode nodes was centered at the frontocentral area. Furthermore, correlation coefficients were calculated between MMN amplitudes and CRS-R scores for each electrode among all participants to generate topographic maps. Meanwhile, a significant negative correlation between the MMN amplitudes elicited by large deviant stimuli and the CRS-R scores was also found at the frontocentral area. In consequence, our results combine the above spatial properties of MMN in patients with DOCs, and provide a more precise location (frontocentral area) at which to evaluate the correlation between clinical electrophysiological assessment and the level of consciousness.
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