The effects of vitamin E supplementation on malondialdehyde as a biomarker of oxidative stress in haemodialysis patients: a systematic review and meta-analysis.
The effects of vitamin E supplementation on malondialdehyde as a biomarker of oxidative stress in haemodialysis patients: a systematic review and meta-analysis.
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DOI：
10.1186/s12882-021-02328-8
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发表时间：
2021-04-09
期刊：
影响因子：
2.3
通讯作者：
McKay GJ
中科院分区：
文献类型：
--
作者：
Bergin P;Leggett A;Cardwell CR;Woodside JV;Thakkinstian A;Maxwell AP;McKay GJ
与一般人群相比，血液透析（HD）患者的氧化应激（OS）水平往往更高，与发病率和过早死亡率增加相关。维生素E（VE）的抗氧化特性降低了OS生物标志物丙二醛（MDA）的水平，但在HD患者中补充VE对MDA的随机对照试验结果不一致。我们对来自VE补充研究的成人HD患者进行了系统回顾和荟萃分析，并测量了MDA。从开始到2020年1月，考虑了MEDLINE和EMBASE的以下检索标准：“透析”和“维生素E或生育酚”和“丙二醛或MDA”。两名评审员独立提取研究数据并评估偏倚风险。测定VE补充前后的平均MDA水平和标准差。标准化平均差（SMD）和标准误计算为人内差异，所有研究中未一致记录测量单位。使用随机效应荟萃分析合并SMD。18项比较的MDA水平SMD在补充VE后的HD患者中显著较低（-1.55;置信区间：-2.17至-0.94，P < 0.00001）。研究之间存在显著水平的异质性（I2值= 91%; P < 0.00001），有证据表明潜在的出版偏倚倾向于较小的研究。我们的研究结果支持使用VE来减少HD患者OS的影响，尽管一些研究所使用的方法学方法的高度异质性和变化突出了进一步研究的必要性。
Haemodialysis (HD) patients tend to have higher levels of oxidative stress (OS), associated with increased morbidity and premature mortality, compared to the general population. Levels of malondialdehyde (MDA), a biomarker of OS, are reduced by the antioxidant properties of vitamin E (VE) but outcomes from randomised control trials of VE supplementation on MDA in HD patients have been inconsistent. We undertook a systematic review and meta-analysis of adult HD patients from VE supplementation studies with measures of MDA. The following search criteria of MEDLINE and EMBASE were considered from inception to January 2020: ‘dialysis’ AND ‘Vitamin E OR tocopherol’ AND ‘malondialdehyde OR MDA’. Two reviewers independently extracted study data and assessed risk of bias. Mean MDA levels and standard deviation were determined before and after VE supplementation. Standardised mean difference (SMD) and standard error were calculated as the within person difference and units of measure were not consistently recorded across all studies. The SMD were pooled using random effects meta-analysis. The SMD of MDA levels from 18 comparisons was significantly lower in HD patients following VE supplementation (− 1.55; confidence interval: − 2.17 to − 0.94, P < 0.00001). There were significant levels of heterogeneity between studies (I2 value = 91%; P < 0.00001) with evidence of potential publication bias toward smaller studies. Our findings support the use of VE to reduce the effects of OS in HD patients although high levels of heterogeneity and variation in the methodological approaches used by some studies highlight the need for further investigation.
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影响因子：
--
作者：
Ayala A;Muñoz MF;Argüelles S
通讯作者：
Argüelles S
影响因子：
4.2
作者：
HARRIS, PL;QUAIFE, ML;SWANSON, WJ
通讯作者：
SWANSON, WJ
DOI：
10.1016/s0735-1097(98)00584-1
发表时间：
1999-02-01
影响因子：
24
作者：
Heitzer, T;Herttuala, SY;Drexler, H
通讯作者：
Drexler, H
DOI：
10.1111/j.1532-5415.1980.tb00123.x
发表时间：
1980-01-01
影响因子：
6.3
作者：
BAKER, H;FRANK, O;JASLOW, SP
通讯作者：
JASLOW, SP
影响因子：
19.6
作者：
Boaz, M;Matas, Z;Smetana, S
通讯作者：
Smetana, S