Estimating the returns to United Kingdom publicly funded musculoskeletal disease research in terms of net value of improved health outcomes.
Estimating the returns to United Kingdom publicly funded musculoskeletal disease research in terms of net value of improved health outcomes.
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DOI：
10.1186/s12961-017-0276-7
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发表时间：
2018-01-10
影响因子：
4
通讯作者：
Grant J
中科院分区：
文献类型：
--
作者：
Glover M;Montague E;Pollitt A;Guthrie S;Hanney S;Buxton M;Grant J
在心血管和癌症研究方法的基础上，我们估计了英国公共和慈善机构资助的肌肉骨骼疾病(MSD)研究的经济回报，这些研究产生于英国改善的健康结果的净值。为了计算英国MSD相关研究的经济回报，我们估计了(1)1970至2013年间英国在MSD相关研究上的公共和慈善支出；(2)从1994年到2013年的优先干预列表中，由质量调整寿命年(QALY)的健康效益(QALY)减去提供该效益的成本得出的净货币效益(NMB)；(3)英国研究可归因于NMB的比例；以及(4)研究资金和健康收益之间经过的时间。从这四个关键要素收集的数据被用来估计与MSD相关的健康福利研究投资的内部回报率(IRR)。我们使用单向敏感性分析对内部收益率估计中的不确定性进行了分析。以2013年价格计算，1970年至2013年与可持续发展有关的研究的总支出为35亿GB，用于估算回报率的1978-1997年期间为14亿GB。在1994-2013年期间，所分析的主要干预措施产生了871,000个QALY，NMB为160亿GB，考虑到由此产生的NHS净成本，QALY的估值为25,000 GB。可归因于联合王国研究的收益比例为30%，从资助到影响MSD治疗的时间为1600年。我们对MSD相关研究的IRR的最佳估计是7%，这与心血管疾病的9%和癌症研究的10%相似。我们对英国MSD相关研究从净健康收益到公共和慈善资金的IRR的估计是相当可观的，这证明在1978至1997年间进行的研究投资是合理的。我们还展示了以前用于评估心血管和癌症研究回报的方法的适用性。不可避免的是，对于这类研究，我们强调了一些重要的假设和警告，这些假设和警告可以为未来的研究提供信息。本文的在线版本(doi：10.1186/s12961-0170276-7)包含补充材料，授权用户可以使用。
Building on an approach applied to cardiovascular and cancer research, we estimated the economic returns from United Kingdom public- and charitable-funded musculoskeletal disease (MSD) research that arise from the net value of the improved health outcomes in the United Kingdom. To calculate the economic returns from MSD-related research in the United Kingdom, we estimated (1) the public and charitable expenditure on MSD-related research in the United Kingdom between 1970 and 2013; (2) the net monetary benefit (NMB), derived from the health benefit in quality adjusted life years (QALYs) valued in monetary terms (using a base-case value of a QALY of £25,000) minus the cost of delivering that benefit, for a prioritised list of interventions from 1994 to 2013; (3) the proportion of NMB attributable to United Kingdom research; and (4) the elapsed time between research funding and health gain. The data collected from these four key elements were used to estimate the internal rate of return (IRR) from MSD-related research investments on health benefits. We analysed the uncertainties in the IRR estimate using a one-way sensitivity analysis. Expressed in 2013 prices, total expenditure on MSD-related research from 1970 to 2013 was £3.5 billion, and for the period used to estimate the rate of return, 1978-1997, was £1.4 billion. Over the period 1994–2013 the key interventions analysed produced 871,000 QALYs with a NMB of £16 billion, allowing for the net NHS costs resulting from them and valuing a QALY at £25,000. The proportion of benefit attributable to United Kingdom research was 30% and the elapsed time between funding and impact of MSD treatments was 16 years. Our best estimate of the IRR from MSD-related research was 7%, which is similar to the 9% for CVD and 10% for cancer research. Our estimate of the IRR from the net health gain to public and charitable funding of MSD-related research in the United Kingdom is substantial, and justifies the research investments made between 1978 and 1997. We also demonstrated the applicability of the approach previously used in assessing the returns from cardiovascular and cancer research. Inevitably, with a study of this kind, there are a number of important assumptions and caveats that we highlight, and these can inform future research. The online version of this article (doi:10.1186/s12961-017-0276-7) contains supplementary material, which is available to authorized users.
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根据改善健康成果的净价值，估计对英国公开资助的与癌症相关的研究的回报。
影响因子：
9.3
作者：
Glover M;Buxton M;Guthrie S;Hanney S;Pollitt A;Grant J
通讯作者：
Grant J
DOI：
10.11138/mltj/2013.3.2.063
发表时间：
2013-04-01
期刊：
Muscles, ligaments and tendons journal
影响因子：
--
作者：
Abate, Michele;Vanni, Daniele;Salini, Vincenzo
通讯作者：
Salini, Vincenzo
影响因子：
4.4
作者：
Beard, Stephen M.;von Scheele, Birgitta G.;Pearson, Isobel V.
通讯作者：
Pearson, Isobel V.
影响因子：
4
作者：
Hanney SR;Castle-Clarke S;Grant J;Guthrie S;Henshall C;Mestre-Ferrandiz J;Pistollato M;Pollitt A;Sussex J;Wooding S
通讯作者：
Wooding S
影响因子：
3.6
作者：
Claxton, Karl;Martin, Steve;Sculpher, Mark
通讯作者：
Sculpher, Mark