Myelin development in cerebral gray and white matter during adolescence and late childhood.
Myelin development in cerebral gray and white matter during adolescence and late childhood.
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DOI：
10.1016/j.neuroimage.2020.117678
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发表时间：
2021-02-15
期刊：
影响因子：
5.7
通讯作者：
Kuhl PK
中科院分区：
文献类型：
--
作者：
Corrigan NM;Yarnykh VL;Hippe DS;Owen JP;Huber E;Zhao TC;Kuhl PK
青少年时期的髓鞘发育由于其与认知、行为和学习的潜在关系而成为越来越受关注的领域。虽然最近的研究表明，白色物质（WM）和灰质（GM）在青春期经历了长期的髓鞘形成，在WM和GM的髓鞘发育之间的定量关系还没有被研究过。我们使用一种新的大分子质子分数（MPF）映射方法定量描述了整个大脑皮质GM、WM和皮质下髓鞘密度对年龄、性别和青春期状态的依赖性。收集了146名青少年（年龄范围9-17岁）的横断面样本的全脑MPF图。从所有脑叶的GM和WM以及皮质下结构中的MPF值计算髓鞘密度。在一般情况下，皮质GM的髓鞘化是广泛的，更显着相关性与年龄比WM。顶叶GM髓鞘形成的年龄依赖性明显强于额叶、枕叶、颞叶和岛叶。与其他脑叶的WM相比，颞叶WM的髓鞘形成与年龄的相关性最强。在所有皮质叶以及双侧皮质下区域平均时，发现雄性的髓鞘密度高于雌性。青春期阶段与髓鞘密度在几个皮质区和皮质下GM显着相关。这些研究结果表明，在整个大脑区域的GM和WM的髓鞘形成的轨迹显着差异，并表明，皮质GM髓鞘形成在青少年发育过程中起着主导作用。
Myelin development during adolescence is becoming an area of growing interest in view of its potential relationship to cognition, behavior, and learning. While recent investigations suggest that both white matter (WM) and gray matter (GM) undergo protracted myelination during adolescence, quantitative relations between myelin development in WM and GM have not been previously studied. We quantitatively characterized the dependence of cortical GM, WM, and subcortical myelin density across the brain on age, gender, and puberty status during adolescence with the use of a novel macromolecular proton fraction (MPF) mapping method. Whole-brain MPF maps from a cross-sectional sample of 146 adolescents (age range 9–17 years) were collected. Myelin density was calculated from MPF values in GM and WM of all brain lobes, as well as in subcortical structures. In general, myelination of cortical GM was widespread and more significantly correlated with age than that of WM. Myelination of GM in the parietal lobe was found to have a significantly stronger age dependence than that of GM in the frontal, occipital, temporal and insular lobes. Myelination of WM in the temporal lobe had the strongest association with age as compared to WM in other lobes. Myelin density was found to be higher in males as compared to females when averaged across all cortical lobes, as well as in a bilateral subcortical region. Puberty stage was significantly correlated with myelin density in several cortical areas and in the subcortical GM. These findings point to significant differences in the trajectories of myelination of GM and WM across brain regions and suggest that cortical GM myelination plays a dominant role during adolescent development.
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影响因子：
4.4
作者：
Helms, Gunther;Dechent, Peter
通讯作者：
Dechent, Peter
DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
青少年和年轻人皮质髓鞘化的区域生长轨迹：纵向验证和功能相关。
影响因子：
3.2
作者：
Kwon D;Pfefferbaum A;Sullivan EV;Pohl KM
通讯作者：
Pohl KM
影响因子：
3.3
作者：
Deoni, Sean C. L.;Rutt, Brian K.;Jones, Derek K.
通讯作者：
Jones, Derek K.
影响因子：
2.8
作者：
Anisimov, Nikolay V.;Pavlova, Olga S.;Yarnykh, Vasily L.
通讯作者：
Yarnykh, Vasily L.