Regional growth trajectories of cortical myelination in adolescents and young adults: longitudinal validation and functional correlates.
Regional growth trajectories of cortical myelination in adolescents and young adults: longitudinal validation and functional correlates.
复制标题
青少年和年轻人皮质髓鞘化的区域生长轨迹：纵向验证和功能相关。
DOI：
10.1007/s11682-018-9980-3
复制
发表时间：
2020-02
影响因子：
3.2
通讯作者：
Pohl KM
中科院分区：
文献类型：
--
作者：
Kwon D;Pfefferbaum A;Sullivan EV;Pohl KM
青春期是认知和情感持续进化的时期，大脑持续发育，涉及突触修剪和皮质髓鞘形成。这项研究的假设是，重度髓鞘形成发生在具有相对直接、预定电路支持单峰感觉或运动功能的皮质区域，并在青春期（12-21岁）直至成年早期（22-35岁）表现出陡峭的发育斜率，此时髓鞘形成进一步减慢。相比之下，浅髓鞘形成发生在具有支持复杂功能的高度可塑性电路的区域，并且遵循延迟的发育轨迹。为了支持这一假设，我们对国家青少年酒精和神经发展联盟 (NCANDA) 和人类连接组项目 (HCP) 提供的公开数据集进行了皮质髓磷脂含量的估计和协调。对 226 名不饮酒至低度饮酒的 NCANDA 青少年的横断面分析显示，单峰初级运动皮层中髓磷脂生长的年龄依赖性轨迹相对较陡，而多峰中/后扣带皮层中的髓磷脂生长轨迹较平坦。当对 HCP 队列中 686 名没有神经精神诊断的年轻人进行相同的分析时，这种持续髓鞘形成的模式显示出较小的增益。重要的是，在 NCANDA 青少年中发现了运动任务与运动或扣带皮层髓磷脂含量之间的预测相关性，支持了这种成像神经测量的功能相关性。此外，通过对皮质髓磷脂进行纵向一致分析来确认区域轨迹斜率。总之，髓磷脂含量和回路复杂性的协调在整个青春期持续发展，有助于表现成熟，并可能代表年轻成年期活跃的皮质发育达到顶峰。
Adolescence is a time of continued cognitive and emotional evolution occurring with continuing brain development involving synaptic pruning and cortical myelination. The hypothesis of this study is that heavy myelination occurs in cortical regions with relatively direct, predetermined circuitry supporting unimodal sensory or motor functions and shows a steep developmental slope during adolescence (12-21 years) until young adulthood (22- 35 years) when further myelination decelerates. By contrast, light myelination occurs in regions with highly plastic circuitry supporting complex functions and follows a delayed developmental trajectory. In support of this hypothesis, cortical myelin content was estimated and harmonized across publicly available datasets provided by the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) and the Human Connectome Project (HCP). The cross-sectional analysis of 226 no-to-low alcohol drinking NCANDA adolescents revealed relatively steeper age-dependent trajectories of myelin growth in unimodal primary motor cortex and flatter age-dependent trajectories in multimodal mid/posterior cingulate cortices. This pattern of continued myelination showed smaller gains when the same analyses were performed on 686 young adults of the HCP cohort free of neuropsychiatric diagnoses. Critically, a predicted correlation between a motor task and myelin content in motor or cingulate cortices was found in the NCANDA adolescents, supporting the functional relevance of this imaging neurometric. Furthermore, the regional trajectory slopes were confirmed by performing longitudinally consistent analysis of cortical myelin. In conclusion, coordination of myelin content and circuit complexity continues to develop throughout adolescence, contributes to performance maturation, and may represent active cortical development climaxing in young adulthood.
登录
查看更多内容
影响因子：
3
作者：
Bock, Nicholas A.;Kocharyan, Ara;Liu, Junjie V.;Silva, Afonso C.
通讯作者：
Silva, Afonso C.
DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
3.4
作者：
Brown, Sandra A.;Brumback, T. Y.;Tapert, Susan F.
通讯作者：
Tapert, Susan F.
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI