Cocaine and Marijuana Polysubstance Use and Cocaine Use Disorder: Investigating Mediated Effects through Patterns of Cocaine Use.
Cocaine and Marijuana Polysubstance Use and Cocaine Use Disorder: Investigating Mediated Effects through Patterns of Cocaine Use.
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DOI：
10.1080/15504263.2020.1849887
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发表时间：
2021-01
影响因子：
2.2
通讯作者：
Cottler LB
中科院分区：
文献类型：
--
作者：
Liu Y;Cheong J;Setlow B;Cottler LB
可卡因的使用正在上升，它与大麻的使用并存。我们研究了终身可卡因+大麻多种物质使用（CM PSU）与仅可卡因和终身可卡因使用障碍（CocUD）之间的关联，并研究了可卡因使用模式的潜在中介作用。从全国酒精和相关疾病流行病学调查中确定了总共2，968名终身可卡因使用者-III。中介分析被用来检查可卡因的使用量，频率和持续时间作为潜在的介质之间的关联CM PSU和CocUD。分别使用并行多中介模型和结构方程模型来检验：（1）可卡因使用量、频率和持续时间的个体贡献，以及（2）由潜在变量指定的集合的组合贡献。可卡因使用者分为2，782名（93.7%）CM多物质使用者和186名（6.3%）可卡因使用者。CM PSU与CocUD风险降低相关，但在包括介质后，这种关联不再显著。单独检查，只有数量被发现是一个显着的调解人以上的频率和持续时间，而三个可卡因使用模式指标的潜变量解释了CM PSU和CocUD之间的总关联的56.6%。与仅可卡因使用者相比，CM多物质使用者不太可能大量使用可卡因;这种较低的可卡因使用强度反过来与CocUD风险降低相关。未来的研究是必要的，以确定CM PSU和减少CocUD之间的关联性质。
Cocaine use is on the rise and it is comorbid with marijuana use. We examined the association between lifetime cocaine + marijuana polysubstance use (CM PSU) versus cocaine only and lifetime cocaine use disorder (CocUD) and examined the potential mediation by cocaine use patterns. A total of 2,968 lifetime cocaine users were identified from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Mediation analysis was utilized to examine cocaine use quantity, frequency, and duration as potential mediators in the association between CM PSU and CocUD. A parallel multiple mediator model and a structural equation model were used, respectively, to examine: (1) the individual contribution of cocaine use quantity, frequency, and duration, and (2) combined contribution as a set specified by a latent variable. Cocaine users were divided into 2,782 (93.7%) CM polysubstance users and 186 (6.3%) cocaine only users. CM PSU was associated with decreased risk of CocUD, but after including the mediators, the association was no longer significant. Examined separately, only quantity was found to be a significant mediator over and above frequency and duration, while the latent variable with three cocaine use pattern indicators explained 56.6% of the total association between CM PSU and CocUD. Compared to cocaine only users, CM polysubstance users were less likely to use cocaine heavily; this lower intensity of cocaine use was in turn associated with decreased risk of CocUD. Future research is warranted to determine the nature of the association between CM PSU and reduced CocUD.
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影响因子：
3.3
作者：
Jones, Abenaa Acheampong;Gerke, Travis;Cottler, Linda B.
通讯作者：
Cottler, Linda B.
影响因子：
56.9
作者：
KANDEL, D
通讯作者：
KANDEL, D
影响因子：
4.2
作者：
John, William S.;Wu, Li-Tzy
通讯作者：
Wu, Li-Tzy
影响因子：
4.2
作者：
Afful, Stephanie E.;Strickland, Jaime R.;Bierut, Laura Jean
通讯作者：
Bierut, Laura Jean
影响因子：
--
作者：
Liu, Yiyang;Elliott, Amy L;Cottler, Linda B
通讯作者：
Cottler, Linda B