The living interface between synthetic biology and biomaterial design.
The living interface between synthetic biology and biomaterial design.
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DOI：
10.1038/s41563-022-01231-3
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发表时间：
2022-04
期刊：
影响因子：
41.2
通讯作者：
中科院分区：
文献类型：
--
作者：
合成生物学最近取得的影响深远的进展为创造新材料提供了令人兴奋的工具。相反，对软凝聚态物质、聚合物和生物材料的基本理解的进步为扩展合成生物学的范围提供了新的途径。广泛而令人兴奋的可能应用范围对解决健康、生物技术和可持续性方面的重大挑战具有重大意义。尽管合成生物学和生物材料的结合具有潜在的变革性影响，但迄今为止，这两个领域的进展大多是分开的。这篇透视图文章回顾了这两个领域的最新关键进展，并提供了在这两个社区之间的接口上进行协作的路线图。我们强调了这种界面在分层结构生物材料开发中的近期应用，从受生物启发的构建块到基于材料和嵌入细胞之间相互作用的感知和响应的“活”材料。
Recent far-reaching advances in synthetic biology have yielded exciting tools for the creation of new materials. Conversely, advances in the fundamental understanding of soft-condensed matter, polymers, and biomaterials offer new avenues to extend the reach of synthetic biology. The broad and exciting range of possible applications have significant implications to address grand challenges in health, biotechnology, and sustainability. Despite the potentially transformative impact that lies at the interface of synthetic biology and biomaterials, the two fields have to date progressed mostly separately. This perspective article provides a review of recent key advances in these two fields, and a roadmap for collaboration at the interface between these two communities. We highlight the near-term applications of this interface to the development of hierarchically structured biomaterials, from bioinspired building blocks to “living” materials that sense and respond based on the reciprocal interactions between materials and embedded cells.
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