The gut-brain dopamine axis: a regulatory system for caloric intake.
The gut-brain dopamine axis: a regulatory system for caloric intake.
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DOI：
10.1016/j.physbeh.2012.02.026
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发表时间：
2012-06-06
影响因子：
2.9
通讯作者：
Yeckel, Catherine W.
中科院分区：
文献类型：
--
作者：
de Araujo, Ivan E.;Ferreira, Jozelia G.;Tellez, Luis A.;Ren, Xueying;Yeckel, Catherine W.
已知摄食后因素通过向中枢神经系统提供关于有机体当前生理状态的反馈信号来强烈调节摄食行为。尤其令人感兴趣的是识别允许大脑感知摄食后信号的生理路径。我们将回顾支持营养物质直接刺激胃肠道导致儿茶酚胺神经递质多巴胺释放的最新证据。此外，直接刺激胃肠道产生的多巴胺流出的变化被发现反映了输液的卡路里负荷，这表明多巴胺信号可能作为中央卡路里传感器发挥作用，根据膳食的卡路里密度调节摄入量。与上述一致，阻断多巴胺信号会扰乱味道-营养关联，并损害在胃内喂养期间维持恒定热量摄入的调节能力。未来的研究必须确定将肠道营养摄入与多巴胺外流联系起来的确切途径。目前的证据表明，吸收前和吸收后通路的作用是平行的，这表明多巴胺系统构成了一个汇聚部位，通过这个部位，不同的生理信号可以对摄取行为进行控制。
Post-ingestive factors are known to strongly modulate feeding behavior by providing feedback signals to the central nervous system on the current physiological state of the organism. Of particular interest is the identification of the physiological pathways that permit the brain to sense post-ingestive signals. We will review recent evidence supporting the concept that direct stimulation of the gastrointestinal tract with nutrients induces release of the catecholamine neurotransmitter dopamine. In addition, changes in dopamine efflux produced by direct stimulation of the gastrointestinal tract were found to reflect the caloric load of the infusates, suggesting that dopamine signaling may function as a central caloric sensor that mediates adjustments in intake according to the caloric density of a meal. Consistent with the above, blockade of dopamine signaling disrupts flavor-nutrient associations and impair the regulatory capacity to maintain constant caloric intake during intra-gastric feeding. Future research must determine the exact pathways linking gut nutrient administration to dopamine efflux. Current evidence points to parallel contributions by pre- and post-absorptive pathways, indicating that dopamine systems constitute a site of convergence through which distinct physiological signals can exert control over ingestive behaviors.
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DOI：
10.1523/jneurosci.3890-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andrews ZB;Erion D;Beiler R;Liu ZW;Abizaid A;Zigman J;Elsworth JD;Savitt JM;DiMarchi R;Tschoep M;Roth RH;Gao XB;Horvath TL
通讯作者：
Horvath TL
影响因子：
4.2
作者：
Jerlhag, Elisabet;Engel, Jorgen A.
通讯作者：
Engel, Jorgen A.
影响因子：
2.9
作者：
Beglinger, C;Degen, L
通讯作者：
Degen, L
影响因子：
3.4
作者：
Jerlhag, Elisabet;Egecioglu, Emil;Engel, Jorgen A.
通讯作者：
Engel, Jorgen A.
影响因子：
56.9
作者：
GRILL, HJ;NORGREN, R
通讯作者：
NORGREN, R