AII amacrine cells in the primate fovea contribute to photopic vision.
AII amacrine cells in the primate fovea contribute to photopic vision.
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DOI：
10.1038/s41598-018-34621-2
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发表时间：
2018-11-06
影响因子：
4.6
通讯作者：
Grünert U
中科院分区：
文献类型：
--
作者：
Strettoi E;Masri RA;Grünert U
AII无长突细胞被认为是视网膜中暗视（夜视）通路中的关键中间神经元。在暗视条件下，视杆信号通过视杆双极细胞传递到AII无长突细胞，AII无长突细胞将视杆信号分成OFF通路（通过甘氨酸能突触）和ON通路（通过间隙连接）。但AII无长突细胞也有一项“日常工作”：在高光照水平下，当视锥细胞活跃时，AII与ON视锥双极细胞的连接提供交叉抑制，以扩大OFF视锥双极细胞的反应范围。AII细胞是否有助于灵长类动物中央凹（其中杆和杆双极细胞是罕见的或不存在）的交叉抑制的问题还没有得到回答。在这里，免疫组织化学和三维重建显示，在猕猴和人类的中央凹钙视网膜蛋白阳性细胞具有AII形态和连接到锥双极细胞。AII连接到锥双极细胞的模式在数量上类似于中央凹外的AII细胞。我们的研究结果支持这样的观点，即在哺乳动物视网膜AII细胞首先演变为锥电路，然后增选处理暗视信号后，杆双极细胞的演变。
The AII amacrine cell is known as a key interneuron in the scotopic (night-vision) pathway in the retina. Under scotopic conditions, rod signals are transmitted via rod bipolar cells to AII amacrine cells, which split the rod signal into the OFF (via glycinergic synapses) and the ON pathway (via gap junctions). But the AII amacrine cell also has a “day job”: at high light levels when cones are active, AII connections with ON cone bipolar cells provide crossover inhibition to extend the response range of OFF cone bipolar cells. The question whether AII cells contribute to crossover inhibition in primate fovea (where rods and rod bipolar cells are rare or absent) has not been answered. Here, immunohistochemistry and three-dimensional reconstruction show that calretinin positive cells in the fovea of macaque monkeys and humans have AII morphology and connect to cone bipolar cells. The pattern of AII connections to cone bipolar cells is quantitatively similar to that of AII cells outside the fovea. Our results support the view that in mammalian retina AII cells first evolved to serve cone circuits, then later were co-opted to process scotopic signals subsequent to the evolution of rod bipolar cells.
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DOI：
10.1007/3-540-26977-0_1
发表时间：
2005-01-01
期刊：
MACULAR DEGENERATION
影响因子：
--
作者：
Hendrickson, A
通讯作者：
Hendrickson, A
影响因子：
2.5
作者：
CHUN, MH;HAN, SH;WASSLE, H
通讯作者：
WASSLE, H
影响因子：
2.5
作者：
Lee, Sammy C. S.;Weltzien, Felix;Gruenert, Ulrike
通讯作者：
Gruenert, Ulrike
影响因子：
1.9
作者：
Demb, Jonathan B.;Singer, Joshua H.
通讯作者：
Singer, Joshua H.
影响因子：
1.9
作者：
Luo, XG;Ghosh, KK;Grünert, U
通讯作者：
Grünert, U