Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19.
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19.
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白细胞介素-6和巨噬细胞趋化蛋白-1增加与COVID-19呼吸衰竭相关
DOI：
10.1038/s41598-020-78710-7
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发表时间：
2020-12-10
影响因子：
4.6
通讯作者：
Dyrhol-Riise AM
中科院分区：
文献类型：
--
作者：
Jøntvedt Jørgensen M;Holter JC;Christensen EE;Schjalm C;Tonby K;Pischke SE;Jenum S;Skeie LG;Nur S;Lind A;Opsand H;Enersen TB;Grøndahl R;Hermann A;Dudman S;Muller F;Ueland T;Mollnes TE;Aukrust P;Heggelund L;Holten AR;Dyrhol-Riise AM
在SARS-CoV-2感染中，迫切需要确定将进展为严重COVID-19并可能受益于靶向治疗的患者。在这项研究中，我们分析了COVID-19患者的血浆细胞因子，并调查了它们与呼吸衰竭（RF）和重症监护室（ICU）治疗的关系。将确诊COVID-19的住院患者（n = 34）招募到前瞻性队列研究中。在入选时以及2-5天和7-10天后收集临床数据和血液样本。RF定义为PaO 2/FiO 2比值（P/F）< 40 kPa。通过人细胞因子27重测定分析血浆细胞因子。患有RF和/或在ICU接受治疗的COVID-19患者显示全身细胞因子水平总体升高。血浆IL-6、IL-8、G-CSF、MCP-1、MIP-1α水平与P/F呈负相关，而IL-6、IP-10、IL-1 ra和MCP-1联合应用与RF的相关性最好（AUC 0.79-0.80，p < 0.05）。在住院期间，IP-10的下降最显著（p < 0.001）。在严重COVID-19患者中存在促炎细胞因子水平升高。IL-6和MCP-1与P/F呈负相关，在ROC分析中AUC最大，应进一步探索其作为生物标志物，以识别有严重RF风险的患者，并作为改善治疗策略的目标。
In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and investigated their association with respiratory failure (RF) and treatment in Intensive Care Unit (ICU). Hospitalized patients (n = 34) with confirmed COVID-19 were recruited into a prospective cohort study. Clinical data and blood samples were collected at inclusion and after 2–5 and 7–10 days. RF was defined as PaO2/FiO2 ratio (P/F) < 40 kPa. Plasma cytokines were analyzed by a Human Cytokine 27-plex assay. COVID-19 patients with RF and/or treated in ICU showed overall increased systemic cytokine levels. Plasma IL-6, IL-8, G-CSF, MCP-1, MIP-1α levels were negatively correlated with P/F, whereas combinations of IL-6, IP-10, IL-1ra and MCP-1 showed the best association with RF in ROC analysis (AUC 0.79–0.80, p < 0.05). During hospitalization the decline was most significant for IP-10 (p < 0.001). Elevated levels of pro-inflammatory cytokines were present in patients with severe COVID-19. IL-6 and MCP-1 were inversely correlated with P/F with the largest AUC in ROC analyses and should be further explored as biomarkers to identify patients at risk for severe RF and as targets for improved treatment strategies.
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影响因子：
25.4
作者：
Guaraldi, Giovanni;Meschiari, Marianna;Mussini, Cristina
通讯作者：
Mussini, Cristina
影响因子：
158.5
作者：
Grein, J.;Ohmagari, N.;Flanigan, T.
通讯作者：
Flanigan, T.
DOI：
10.1631/jzus.2005.b1045
发表时间：
2005-11-01
期刊：
Journal of Zhejiang University. Science. B
影响因子：
--
作者：
Gruys, E;Toussaint, M J M;Koopmans, S J
通讯作者：
Koopmans, S J
影响因子：
100.3
作者：
Chen, Zeyu;John Wherry, E.
通讯作者：
John Wherry, E.
影响因子：
3.8
作者：
Henno, Linda Torrissen;Storjord, Min;Brekke, Ole-Lars
通讯作者：
Brekke, Ole-Lars