Does shear wave ultrasound independently predict axillary lymph node metastasis in women with invasive breast cancer?
Does shear wave ultrasound independently predict axillary lymph node metastasis in women with invasive breast cancer?
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DOI：
10.1007/s10549-013-2747-z
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发表时间：
2014-01
影响因子：
3.8
通讯作者：
Vinnicombe, Sarah
中科院分区：
文献类型：
--
作者：
Evans, Andrew;Rauchhaus, Petra;Whelehan, Patsy;Thomson, Kim;Purdie, Colin A.;Jordan, Lee B.;Michie, Caroline O.;Thompson, Alastair;Vinnicombe, Sarah
剪切波弹性成像（SWE）显示出作为灰阶超声检查的辅助手段评估乳腺肿块的前景。在乳腺癌中，SWE上较高的病变硬度已被证明与预后不良的特征相关。本研究的目的是评估SWE时的病变硬度是否是淋巴结受累的独立预测因素。接受过SWE检查的浸润性乳腺癌患者接受了初次手术治疗。对396例连续患者的数据进行了回顾性分析。使用SuperSonic Imagine Ltd.的Aixplorer®超声仪获得平均硬度值。测量值取自位于异常最坚硬部分上方的感兴趣区域。从两个正交图像平面中的每一个获得的平均刚度值的平均值用于分析。采用单变量和多变量logistic回归分析评估淋巴结受累与平均病变硬度、浸润性癌大小、组织学分级、肿瘤类型、ER表达、HER-2状态和血管浸润之间的关系。在单变量分析中，浸润性大小、组织学分级、HER-2状态、血管浸润、肿瘤类型和平均硬度与淋巴结受累显著相关。平均硬度150 kPa的肿瘤的淋巴结受累率为7%<50 kPa to 41 % for tumours with a mean stiffness of >。在多变量分析中，浸润性大小、肿瘤类型、血管浸润和平均硬度保持独立显著性。平均硬度在SWE是一个独立的预测淋巴结转移，因此可以提供额外的预后信息提供传统的术前肿瘤评估和分期。
Shear wave elastography (SWE) shows promise as an adjunct to greyscale ultrasound examination in assessing breast masses. In breast cancer, higher lesion stiffness on SWE has been shown to be associated with features of poor prognosis. The purpose of this study was to assess whether lesion stiffness at SWE is an independent predictor of lymph node involvement. Patients with invasive breast cancer treated by primary surgery, who had undergone SWE examination were eligible. Data were retrospectively analysed from 396 consecutive patients. The mean stiffness values were obtained using the Aixplorer® ultrasound machine from SuperSonic Imagine Ltd. Measurements were taken from a region of interest positioned over the stiffest part of the abnormality. The average of the mean stiffness value obtained from each of two orthogonal image planes was used for analysis. Associations between lymph node involvement and mean lesion stiffness, invasive cancer size, histologic grade, tumour type, ER expression, HER-2 status and vascular invasion were assessed using univariate and multivariate logistic regression. At univariate analysis, invasive size, histologic grade, HER-2 status, vascular invasion, tumour type and mean stiffness were significantly associated with nodal involvement. Nodal involvement rates ranged from 7 % for tumours with mean stiffness <50 kPa to 41 % for tumours with a mean stiffness of >150 kPa. At multivariate analysis, invasive size, tumour type, vascular invasion, and mean stiffness maintained independent significance. Mean stiffness at SWE is an independent predictor of lymph node metastasis and thus can confer prognostic information additional to that provided by conventional preoperative tumour assessment and staging.
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DOI：
10.1001/jama.2011.593
发表时间：
2011-05-11
期刊：
JAMA
影响因子：
--
作者：
Hatzis C;Pusztai L;Valero V;Booser DJ;Esserman L;Lluch A;Vidaurre T;Holmes F;Souchon E;Wang H;Martin M;Cotrina J;Gomez H;Hubbard R;Chacón JI;Ferrer-Lozano J;Dyer R;Buxton M;Gong Y;Wu Y;Ibrahim N;Andreopoulou E;Ueno NT;Hunt K;Yang W;Nazario A;DeMichele A;O'Shaughnessy J;Hortobagyi GN;Symmans WF
通讯作者：
Symmans WF
影响因子：
19.7
作者：
Evans, Andrew;Whelehan, Patsy;Thompson, Alastair
通讯作者：
Thompson, Alastair
影响因子：
6
作者：
Conklin, Matthew W.;Eickhoff, Jens C.;Keely, Patricia J.
通讯作者：
Keely, Patricia J.
影响因子：
3.8
作者：
Youk, Ji Hyun;Gweon, Hye Mi;Jeong, Joon
通讯作者：
Jeong, Joon
影响因子：
3.8
作者：
Chen, Li-Ching;Tu, Shih-Hsin;Ho, Yuan-Soon
通讯作者：
Ho, Yuan-Soon