Effects of an experimentally induced rhinovirus cold on sleep, performance, and daytime alertness.
Effects of an experimentally induced rhinovirus cold on sleep, performance, and daytime alertness.
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DOI：
10.1016/s0031-9384(00)00322-x
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发表时间：
2000-10-01
影响因子：
2.9
通讯作者：
Roth T
中科院分区：
文献类型：
--
作者：
Drake CL;Roehrs TA;Royer H;Koshorek G;Turner RB;Roth T
研究目的：越来越多的证据表明，普通感冒会损害心理警觉性。这使得一些研究人员假设这些疾病也可能对睡眠产生破坏性影响。虽然一些自我报告的研究表明，病毒性疾病可能会影响睡眠参数，但没有研究评估病毒感染后的多导睡眠图记录。设计：平行对照组比较。设置：睡眠实验室在一个大型城市医疗中心。参与者：21名对鼻病毒23型易感的男性和女性。干预措施：鼻腔接种鼻病毒23型。测量：病毒接种后5个晚上（2300-0700 h）的多导睡眠图记录睡眠。每天两次（1030和1430小时）的性能评估，在每个实验日使用听觉警觉和分散注意力的任务。在研究期间，每天进行多次睡眠潜伏期试验（MPEST）。结果如下：在有症状的个体中，与潜伏期相比，病毒活动期（实验日/夜3-5）的总睡眠时间平均减少23分钟，巩固睡眠平均减少36分钟，睡眠效率平均降低5%。心理表现受损。这些变化明显大于在无症状个体中观察到的变化。结论：在疾病的初始活动阶段，普通感冒会对有症状的个体的睡眠和精神表现产生不利影响。
Study objectives: There is accumulating evidence that the common cold produces impairments in psychomotor vigilance. This has led some investigators to hypothesize that such illnesses may also have disruptive effects on sleep. While several self-report studies suggest that viral illness may influence sleep parameters, no studies have assessed polysomnographically recorded sleep following viral infections. Design: Parallel control group comparison. Setting: Sleep laboratory in a large urban medical center. Participants: Twenty-one men and women with susceptibility to the rhinovirus type 23. Interventions: Nasal inoculation with rhinovirus type 23. Measurements: Polysomnographically recorded sleep for five nights (2300–0700 h) post-viral inoculation. Twice daily (1030 and 1430 h) performance assessment during each experimental day using auditory vigilance and divided attention tasks. A multiple sleep latency test (MSLT) was performed daily for the duration of the study. Results: In symptomatic individuals, total sleep time decreased an average of 23 min, consolidated sleep decreased an average of 36 min, and sleep efficiency was reduced by an average of 5% during the active viral period (experimental days/nights 3–5) compared with the incubation period. Psychomotor performance was impaired. These changes were significantly greater than those observed in asymptomatic individuals. Conclusions: The common cold can have detrimental effects on sleep and psychomotor performance in symptomatic individuals during the initial active phase of the illness.
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影响因子：
6.1
作者：
BARROW, GI;HIGGINS, PG;TYRRELL, DAJ
通讯作者：
TYRRELL, DAJ
影响因子：
2.9
作者：
Hall, S;Smith, A
通讯作者：
Smith, A
影响因子：
3.7
作者：
CARSKADON, MA;DEMENT, WC
通讯作者：
DEMENT, WC
影响因子：
6.9
作者：
SMITH, AP;TYRRELL, DAJ;WILLMAN, JS
通讯作者：
WILLMAN, JS
影响因子：
2.2
作者：
STEPANSKI, E;LAMPHERE, J;ROTH, T
通讯作者：
ROTH, T