Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis: a protective role for shared epitope.
Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis: a protective role for shared epitope.
复制标题
DOI：
10.1371/journal.pone.0033133
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Tohma S
中科院分区：
文献类型：
--
作者：
Furukawa H;Oka S;Shimada K;Sugii S;Ohashi J;Matsui T;Ikenaka T;Nakayama H;Hashimoto A;Takaoka H;Arinuma Y;Okazaki Y;Futami H;Komiya A;Fukui N;Nakamura T;Migita K;Suda A;Nagaoka S;Tsuchiya N;Tohma S
间质性肺疾病（ILD）常与类风湿关节炎（RA）相关，是关节外表现之一。许多关于人类白细胞抗原（HLA）等位基因与RA关联的研究已被报道，但很少有在RA亚群伴ILD的研究得到证实。在这项研究中，我们研究了HLA II类等位基因与RA中ILD的关系。基于胸部计算机断层扫描图像的发现，对450名被诊断或未被诊断为ILD的日本RA患者进行了HLA-DRB1、DQB1和DPB1的关联研究。出乎意料的是，HLA-DRB1*04（校正后P [Pc] = 0.0054，优势比[OR] 0.57）、共享表位（SE） （P = 0.0055, OR 0.66）和DQB1*04 （Pc = 0.0036, OR 0.57）与ILD风险显著降低相关。DRB1*16 （Pc = 0.0372, OR 15.21）、DR2血清学组（DRB1*15和*16等位基因）（P = 0.0020, OR 1.75）和DQB1*06 （Pc = 0.0333, OR 1.57）与ILD风险显著相关。HLA-DRB1 SE与日本RA患者ILD风险降低相关，而DR2血清学组（DRB1*15和*16）与ILD风险增加相关。
Interstitial Lung Disease (ILD) is frequently associated with Rheumatoid Arthritis (RA) as one of extra-articular manifestations. Many studies for Human Leukocyte Antigen (HLA) allelic association with RA have been reported, but few have been validated in an RA subpopulation with ILD. In this study, we investigated the association of HLA class II alleles with ILD in RA. An association study was conducted on HLA-DRB1, DQB1, and DPB1 in 450 Japanese RA patients that were or were not diagnosed with ILD, based on the findings of computed tomography images of the chest. Unexpectedly, HLA-DRB1*04 (corrected P [Pc] = 0.0054, odds ratio [OR] 0.57), shared epitope (SE) (P = 0.0055, OR 0.66) and DQB1*04 (Pc = 0.0036, OR 0.57) were associated with significantly decreased risk of ILD. In contrast, DRB1*16 (Pc = 0.0372, OR 15.21), DR2 serological group (DRB1*15 and *16 alleles) (P = 0.0020, OR 1.75) and DQB1*06 (Pc = 0.0333, OR 1.57, respectively) were significantly associated with risk of ILD. HLA-DRB1 SE was associated with reduced, while DR2 serological group (DRB1*15 and *16) with increased, risk for ILD in Japanese patients with RA.
登录
查看更多内容
影响因子：
4.9
作者：
Turesson C;Schaid DJ;Weyand CM;Jacobsson LT;Goronzy JJ;Petersson IF;Sturfelt G;Nyhäll-Wåhlin BM;Truedsson L;Dechant SA;Matteson EL
通讯作者：
Matteson EL
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
5.3
作者：
Falfán-Valencia, R;Camarena, A;Selman, M
通讯作者：
Selman, M
影响因子：
--
作者：
Sirikong, M;Tsuchiya, N;Tokunaga, K
通讯作者：
Tokunaga, K
影响因子：
19.7
作者：
Webb, WR
通讯作者：
Webb, WR