Tumorigenesis as a process of gradual loss of original cell identity and gain of properties of neural precursor/progenitor cells.
Tumorigenesis as a process of gradual loss of original cell identity and gain of properties of neural precursor/progenitor cells.
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肿瘤发生是一个逐渐丧失原始细胞特性并获得神经前体/祖细胞特性的过程
DOI：
10.1186/s13578-017-0188-9
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发表时间：
2017
影响因子：
7.5
通讯作者：
Cao Y
中科院分区：
文献类型：
--
作者：
Cao Y
癌症是一种复杂的疾病，到目前为止对其病因还没有一个统一的解释。我们最近的工作表明，癌细胞与胚胎神经细胞具有相似的调节网络和特征。在此基础上，我将更详细地阐述肿瘤与神经细胞之间的关系。我收集了许多其他研究中癌症发展的各个方面的证据，并整合了胚胎发育和进化过程中癌细胞特性、细胞命运规范的研究信息。这些信息的综合有力地支持了癌细胞与神经祖细胞/干细胞比与间充质型细胞有更多的相似之处，并且肿瘤的发生代表了细胞或谱系特征的逐渐丧失和神经细胞特征的获得的过程。我还讨论了癌症EMT，这是一个备受争议的概念，以及EMT在癌症发生和发展中的真正意义。这一综合为肿瘤发生的统一解释和以前未被认识到的性质提供了新的见解，这可能无法通过单个分子事件的研究揭示。本文还将根据所提出的肿瘤发生模型对癌症研究提出一些简要建议。
Cancer is a complex disease without a unified explanation for its cause so far. Our recent work demonstrates that cancer cells share similar regulatory networks and characteristics with embryonic neural cells. Based on the study, I will address the relationship between tumor and neural cells in more details. I collected the evidence from various aspects of cancer development in many other studies, and integrated the information from studies on cancer cell properties, cell fate specification during embryonic development and evolution. Synthesis of the information strongly supports that cancer cells share much more similarities with neural progenitor/stem cells than with mesenchymal-type cells and that tumorigenesis represents a process of gradual loss of cell or lineage identity and gain of characteristics of neural cells. I also discuss cancer EMT, a concept having been under intense debate, and possibly the true meaning of EMT in cancer initiation and development. This synthesis provides fresh insights into a unified explanation for and a previously unrecognized nature of tumorigenesis, which might not be revealed by studies on individual molecular events. The review will also present some brief suggestions for cancer research based on the proposed model of tumorigenesis.
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影响因子：
4
作者：
Alexandrov, Ludmil B.;Stratton, Michael R.
通讯作者：
Stratton, Michael R.
影响因子：
16.6
作者：
Chen, Han;Lin, Fangqin;He, Xionglei
通讯作者：
He, Xionglei
影响因子：
11.5
作者：
Ayala, Gustavo E.;Dai, Hong;Rowley, David
通讯作者：
Rowley, David
DOI：
10.1073/pnas.67.3.1521
发表时间：
1970-01-01
影响因子：
11.1
作者：
BATKIN, S;PIETTE, LH;WILDMAN, E
通讯作者：
WILDMAN, E
影响因子：
5.2
作者：
Alfarouk KO;Shayoub ME;Muddathir AK;Elhassan GO;Bashir AH
通讯作者：
Bashir AH