Association of maternal pre-pregnancy BMI and breastfeeding with NAFLD in young adults: a parental negative control study.
Association of maternal pre-pregnancy BMI and breastfeeding with NAFLD in young adults: a parental negative control study.
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DOI：
10.1016/j.lanepe.2021.100206
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Hickman M
中科院分区：
文献类型：
--
作者：
Abeysekera KW;Orr JG;Madley-Dowd P;Fernandes GS;Zuccolo L;Gordon FH;Lawlor DA;Heron J;Hickman M
非酒精性脂肪性肝病（NAFLD）的发生中母婴二分体的重要性越来越受到关注。雅芳父母和儿童纵向研究（ALSPAC）显示，在24岁时，通过瞬态弹性成像和受控衰减参数（CAP）测量，五分之一的人患有NAFLD。我们的目的是调查母乳喂养时间和母亲孕前BMI与年轻成年期后代NAFLD之间的关系。4021名参与者参加了使用Echosens 502 Touch®进行FibroScan和CAP测量的诊所。440名酒精使用障碍的参与者被排除在外。排除了100例非单胎妊娠的后代。分析了2961个NAFLD的有效CAP测量值。感兴趣的暴露包括任何持续时间的母乳喂养、≥ 6个月的纯母乳喂养和母亲孕前BMI。多变量回归模型估计了24岁时NAFLD的几率。我们进行了父亲阴性对照试验，以探讨孕前BMI分析中的残留混杂因素。纯母乳喂养和非纯母乳喂养≥6个月对后代的NAFLD具有保护作用，（OR 0.92 [95%CI 0.66 ~ 1.27]和OR 0.90 [0.67 ~ 1.21]），孕前母亲BMI和父亲BMI超重者子代NAFLD的OR分别为2.09 [1.62 ~ 2.68]和1.09 [1.62 ~ 2.68]。33 [95%CI 1.07 ~ 1.65]，效应量比值OR为1.57 [1.11 ~ 2.22]。同样，孕前母亲BMI和父亲BMI肥胖的后代NAFLD的OR分别为2.66 [1.71 - 4.14]和1.35 [0.91 - 2.00]，效应量比值为1.98 [1.05 - 3.74]。较高的母亲孕前BMI与后代NAFLD相关，解释了共同的父母混杂因素。我们没有重复以前的工作，发现母乳喂养和NAFLD之间有很强的联系。英国医学研究理事会，英国酒精研究，大卫告诉慈善信托
The importance of the maternal-infant dyad in the genesis of nonalcoholic fatty liver disease (NAFLD) is of increasing interest. The Avon Longitudinal Study of Parents and Children (ALSPAC) showed that at age 24, 1 in 5 had NAFLD measured by transient elastography and controlled attenuation parameter (CAP). Our aim was to investigate the association between breastfeeding duration and maternal pre-pregnancy BMI on offspring NAFLD in young adulthood. 4021 participants attended clinic for FibroScan and CAP measurement using Echosens 502 Touch®. 440 participants with Alcohol Use Disorders were excluded. Offspring of 100 non-singleton pregnancies were excluded. 2961 valid CAP measurements for NAFLD were analysed. Exposures of interest were breastfeeding of any duration, ≥6months exclusive breastfeeding, and maternal pre-pregnancy BMI. Multivariable regression models estimated the odds of NAFLD at 24 years. We performed a paternal negative control test to explore residual confounding in the analyses of pre-pregnancy BMI. There was a modest inverse association of exclusive and non-exclusive breastfeeding ≥6 months having a protective effect on NAFLD in offspring (OR 0·92 [95%CI 0·66-1·27] and OR 0·90 [0·67-1·21] respectively).The odds of offspring NAFLD in overweight pre-pregnancy maternal BMI and paternal BMI was OR 2·09 [1·62-2·68] and OR 1·33 [95%CI 1·07-1·65] respectively, with the ratio of effect sizes OR 1·57 [1·11-2·22]. Similarly, odds of offspring NAFLD with obese pre-pregnancy maternal BMI and paternal BMI was OR 2·66 [1·71-4·14] and OR 1·35 [0·91-2·00] respectively, with the ratio of effect sizes OR 1·98 [1·05-3·74]. Higher maternal pre-pregnancy BMI was associated with offspring NAFLD, having accounted for shared parental confounding. We did not replicate previous work that found a strong association between breastfeeding and NAFLD. Medical Research Council UK, Alcohol Research UK, David Telling Charitable Trust
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影响因子：
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作者：
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