The impact of maternal obesity and breast milk inflammation on developmental programming of infant growth.
The impact of maternal obesity and breast milk inflammation on developmental programming of infant growth.
复制标题
母亲肥胖和母乳炎症对婴儿生长发育规划的影响。
DOI：
10.1038/s41430-020-00720-5
复制
发表时间：
2021-01
影响因子：
4.7
通讯作者：
Sen S
中科院分区：
文献类型：
--
作者：
Enstad S;Cheema S;Thomas R;Fichorova RN;Martin CR;O'Tierney-Ginn P;Wagner CL;Sen S
关于母亲肥胖如何影响母乳（BM）成分以及BM成分如何影响生长的知之甚少。我们试图确定母体体重指数（BMI）对BM炎症和氧化应激标志物的作用，并描述这些BM标志物对婴儿生长的作用。这是对40对母婴的二次分析。我们首先评估了产后1个月（V1）和4个月（V4）时母体BMI与BM标志物（omega-6：omega-3多不饱和脂肪酸比例（n-6：n-3 PUFA）、瘦素、白细胞介素（IL）-8，IL-6，IL-1β和丙二醛（MDA））浓度之间的相关性。然后，我们研究了从出生到7个月的婴儿生长轨迹的BM标志物之间的关联。母体BMI较高与BM n-6：n-3 PUFA（V1 β=0.12，95% CI 0.01，0.2; V4 β=0.13，95% CI 0.01，0.3）和瘦素（V1 β=107，95% CI 29，184; V4 β=254，95% CI 105，403）浓度较高相关。随着时间的推移，暴露于高BM n-6：n-3 PUFA的婴儿的BMI z评分较高（p=0.01）。较高的BM瘦素与V4时较低的婴儿脂肪质量百分比相关（β=−9，95%CI −17，−0.6）。暴露于高BM IL-8、IL-6或IL-1β的婴儿随时间推移具有较高的体重z评分（IL-8 p<0.001; IL-6 p<0.001; IL-1β p=0.02）。BM MDA与母亲BMI或婴儿生长之间无相关性。较高的母亲BMI与较高的BM n-6：n-3 PUFA和瘦素浓度相关。此外，较高的BM n-6：n-3 PUFA和炎性细胞因子与婴儿期体重增加加速相关。
Little is known about how maternal obesity impacts breast milk (BM) composition and how BM composition may impact growth. We sought to determine the role of maternal body mass index (BMI) on BM inflammatory and oxidative stress markers and to delineate the role of these BM markers on infant growth. This was a secondary analysis of 40 mother-infant dyads. We first assessed the association between maternal BMI and BM marker (omega-6:omega-3 polyunsaturated fatty acid ratio (n-6:n-3 PUFA), leptin, interleukin (IL)-8, IL-6, IL-1β and malondialdehyde (MDA)) concentration at one (V1) and four (V4) months postpartum. We then examined the association between BM markers on infant growth trajectory from birth to seven months. Higher maternal BMI was associated with higher BM n-6:n-3 PUFA (V1 β=0.12, 95% CI 0.01, 0.2; V4 β=0.13, 95% CI 0.01, 0.3) and leptin (V1 β=107, 95% CI 29, 184; V4 β=254, 95% CI 105, 403) concentrations. Infants exposed to high BM n-6:n-3 PUFA had higher BMI z-scores over time (p=0.01). Higher BM leptin was associated with lower infant percent fat mass at V4 (β=−9, 95% CI −17, −0.6). Infants exposed to high BM IL-8, IL-6, or IL-1β had higher weight z-scores over time (IL-8 p<0.001; IL-6 p<0.001; IL-1β p=0.02). There was no association between BM MDA and maternal BMI or infant growth. Higher maternal BMI is associated with higher BM n-6:n-3 PUFA and leptin concentrations. In addition, higher BM n-6:n-3 PUFA and inflammatory cytokines were associated with accelerated weight gain in infancy.
登录
查看更多内容
影响因子：
3.8
作者：
Huh JY;Park YJ;Ham M;Kim JB
通讯作者：
Kim JB
影响因子：
9.1
作者：
Hawkes, JS;Bryan, DL;Gibson, RA
通讯作者：
Gibson, RA
影响因子：
82.9
作者：
LONNQVIST, F;ARNER, P;SCHALLING, M
通讯作者：
SCHALLING, M
影响因子：
8
作者：
Hollis, Bruce W.;Wagner, Carol L.;Hulsey, Thomas C.
通讯作者：
Hulsey, Thomas C.
影响因子：
7.1
作者：
Jensen, CL;Maude, M;Heird, WC
通讯作者：
Heird, WC