A Retrospective 2D Morphometric Analysis of Adult Female Chiari Type I Patients with Commonly Reported and Related Conditions.
A Retrospective 2D Morphometric Analysis of Adult Female Chiari Type I Patients with Commonly Reported and Related Conditions.
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经常报告且相关疾病的成年女性Chiari I型患者的回顾性2D形态分析。
DOI：
10.3389/fnana.2018.00002
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发表时间：
2018
影响因子：
2.9
通讯作者：
Loth F
中科院分区：
文献类型：
--
作者：
Eppelheimer MS;Houston JR;Bapuraj JR;Labuda R;Loth DM;Braun AM;Allen NJ;Heidari Pahlavian S;Biswas D;Urbizu A;Martin BA;Maher CO;Allen PA;Loth F
目的：研究人员试图通过扁桃体位置(TP)以外的形态测量来更好地了解Chiari I型畸形(CMI)。与健康对照组相比，CMI患者大脑和颅颈交界处的软组织和骨结构已被证明是不同的。然而，一些形态特征与CMI并没有一致的联系。CMI还与不同的流行状况(PC)有关，如脊髓空洞症、假瘤、Ehler-Danlos综合征(EDS)、脊柱侧弯和颅颈不稳。这项研究的目的有两个：(1)确定PC独特的形态特征，(2)更好地解释CMI病例对照比较不一致的结果。方法：通过网络访问的自我报告数据库Chiari1000获取图像、人口统计和个人计算机信息。对236例成年女性CMI患者和140例健康女性患者的颅脑MRI图像进行了28次形态测量(MMS)。使用Customer软件测量每个参与者的后颅窝(PCF)间隔、颅颈交界处、口腔和颅内矢状面图像上的28个结构。结果：对成年女性的形态计量学分析表明，患有脊髓空洞症的CMI参与者的McRAE线长度比没有脊髓空洞症的患者要小。有EDS的CMI患者的TP低于无EDS的CMI患者。与无脊柱侧弯的患者相比，有脊柱侧弯的CMI患者的后路轴线距离显著延长。CMI参与者在使用特定PC和不使用特定PC之间没有发现其他彩信不同。研究发现，无论PC如何，CMI参与者和健康对照组之间的四个形态测量学差异始终不同：CMI参与者的TP较大，斜坡长度、顶端和穹隆高度较小。结论：脊髓空洞症、EDS和脊柱侧弯是唯一在CMI参与者之间表现出显著形态测量差异的PC。此外，在健康对照组和CMI参与者之间，发现四个基于矢状面中段MR的MMS显著不同，无论是否存在一台或多台PC。这项研究表明，并存疾病的患病率与CMI的形态没有很强的相关性，放射学文献中不一致的发现不能用CMI研究样本中不同的并存疾病患病率来解释。
Purpose: Researchers have sought to better understand Chiari type I malformation (CMI) through morphometric measurements beyond tonsillar position (TP). Soft tissue and bone structures within the brain and craniocervical junction have been shown to be different for CMI patients compared to healthy controls. Yet, several morphological characteristics have not been consistently associated with CMI. CMI is also associated with different prevalent conditions (PCs) such as syringomyelia, pseudotumor, Ehlers-Danlos syndrome (EDS), scoliosis, and craniocervical instability. The goal of this study was two-fold: (1) to identify unique morphological characteristics of PCs, and (2) to better explain inconsistent results from case-control comparisons of CMI. Methods: Image, demographic, and PC information was obtained through the Chiari1000, a self-report web-accessed database. Twenty-eight morphometric measurements (MMs) were performed on the cranial MR images of 236 pre-surgery adult female CMI participants and 140 female healthy control participants. Custom software was used to measure 28 structures within the posterior cranial fossa (PCF) compartment, craniocervical junction, oral cavity, and intracranial area on midsagittal MR images for each participant. Results: Morphometric analysis of adult females indicated a smaller McRae line length in CMI participants with syringomyelia compared to those without syringomyelia. TP was reduced in CMI participants with EDS than those without EDS. Basion to posterior axial line was significantly longer in CMI participants with scoliosis compared to those without scoliosis. No additional MMs were found to differ between CMI participants with and without a specific PC. Four morphometric differences were found to be consistently different between CMI participants and healthy controls regardless of PC: larger TP and a smaller clivus length, fastigium, and corpus callosum height in CMI participants. Conclusion: Syringomyelia, EDS, and scoliosis were the only PCs that showed significant morphometric differences between CMI participants. Additionally, four midsagittal MR-based MMs were found to be significantly different between healthy controls and CMI participants regardless of the presence of one or more PCs. This study suggests that the prevalence of comorbid conditions are not strongly related to CMI morphology, and that inconsistent findings in the radiographic literature cannot be explained by varying prevalence of comorbid conditions in CMI study samples.
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影响因子：
2.4
作者：
Karagöz, F;Izgi, N;Sencer, SK
通讯作者：
Sencer, SK
影响因子：
1.9
作者：
Depreitere, B;Van Calenbergh, F;Plets, C
通讯作者：
Plets, C
影响因子：
1.9
作者：
Klekamp, Joerg
通讯作者：
Klekamp, Joerg
影响因子：
3
作者：
Brockmeyer, D;Gollogly, S;Smith, JT
通讯作者：
Smith, JT
影响因子：
--
作者：
Aydin, S;Hanimoglu, H;Kaynar, MY
通讯作者：
Kaynar, MY