Epidemiological Profile and Risk Factors for Acquiring HBV and/or HCV in HIV-Infected Population Groups in Nepal.
Epidemiological Profile and Risk Factors for Acquiring HBV and/or HCV in HIV-Infected Population Groups in Nepal.
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DOI：
10.1155/2018/9241679
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发表时间：
2018
影响因子：
--
通讯作者：
Gupta BP
中科院分区：
文献类型：
--
作者：
Bhattarai M;Baniya JB;Aryal N;Shrestha B;Rauniyar R;Adhikari A;Koirala P;Oli PK;Pandit RD;Stein DA;Gupta BP
在尼泊尔，艾滋病毒感染者中普遍存在乙肝病毒和丙型肝炎病毒感染。这项研究的目的是调查尼泊尔弱势HIV阳性人群中感染乙肝病毒和/或丙型肝炎病毒的流行病学概况和危险因素。我们对加德满都国家公共卫生实验室的HIV阳性患者的血液样本进行了回顾性研究，以检测乙肝表面抗原、HBeAg和抗丙型肝炎病毒抗体、HIV病毒载量和CD4+T细胞计数。在579名调查对象中，HIV-HBV型、HIV-HCV型和HIV-HBV型丙型肝炎混合感染率分别为3.62%、2.93%和0.34%。多因素回归分析显示，HIV阳性外来务工人员的配偶合并感染乙肝病毒的风险显著，而HIV感染者年龄40岁是合并感染丙型肝炎病毒的显著危险因素。总体而言，我们的研究表明，弱势群体，如静脉注射吸毒者、外来务工人员及其配偶、女性性工作者和与感染艾滋病毒的男性发生性行为的男性，感染病毒性肝炎的风险很高，而且持续存在。我们的结论是，尼泊尔的艾滋病毒患者应该定期接受乙肝和丙型肝炎诊断筛查。
HBV and HCV infections are widespread among the HIV-infected individuals in Nepal. The goals of this study were to investigate the epidemiological profile and risk factors for acquiring HBV and/or HCV coinfection in disadvantaged HIV-positive population groups in Nepal. We conducted a retrospective study on blood samples from HIV-positive patients from the National Public Health Laboratory at Kathmandu to assay for HBsAg, HBeAg, and anti-HCV antibodies, HIV viral load, and CD4+ T cell count. Among 579 subjects, the prevalence of HIV-HBV, HIV-HCV, and HIV-HBV-HCV coinfections was 3.62%, 2.93%, and 0.34%, respectively. Multivariate regression analysis indicated that spouses of HIV-positive migrant labourers were at significant risk for coinfection with HBV infection, and an age of >40 years in HIV-infected individuals was identified as a significant risk factor for HCV coinfection. Overall our study indicates that disadvantaged population groups such as intravenous drug users, migrant workers and their spouses, female sex workers, and men who have sex with HIV-infected men are at a high and persistent risk of acquiring viral hepatitis. We conclude that Nepalese HIV patients should receive HBV and HCV diagnostic screening on a regular basis.
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影响因子：
168.9
作者：
Schweitzer, Aparna;Horn, Johannes;Ott, Joerdis J.
通讯作者：
Ott, Joerdis J.
影响因子：
8.4
作者：
Ionita, G.;Malviya, A.;Dixit, S.
通讯作者：
Dixit, S.
DOI：
10.1080/09540121.2015.1109582
发表时间：
2016-04-02
影响因子：
1.7
作者：
Moayedi-Nia, Saeedeh;Jozani, Zahra Bayat;Mohraz, Minoo
通讯作者：
Mohraz, Minoo
影响因子：
3.3
作者：
Poudel, KC;Okumura, J;Wakai, S
通讯作者：
Wakai, S
影响因子：
3.7
作者：
Kinkel HT;Karmacharya D;Shakya J;Manandhar S;Panthi S;Karmacharya P;Sitaula D;Thapaliya R;K C P;Rai A;Dixit S
通讯作者：
Dixit S